Zic2 - zinc finger protein of the cerebellum 2 Gene

Mus musculus

Also known as Ku; HPE5

Gene ID: 22772 | Gene type: protein coding

About Zic2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in regulation of transcription, DNA-templated; retinal ganglion cell axon guidance; and visual perception. Acts upstream of or within several processes, including cilium organization; nervous system development; and positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; eye; and neural ectoderm. Used to study holoprosencephaly 5 and schizophrenia. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Orthologous to human ZIC2 (Zic family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Zic2 Products(1)

mRNA	Protein	Name
NM_009574.3	NP_033600.3	zinc finger protein ZIC 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15465018	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11053430	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11053430	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11053430	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18298960	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	20676059	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11238441	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in axial mesoderm development	IGI IGI: Inferred from genetic interaction	17490632	MGI
acts upstream of or within central nervous system development	IGI IGI: Inferred from genetic interaction	11756505	MGI
involved in central nervous system segmentation	IGI IGI: Inferred from genetic interaction	17490632	MGI
acts upstream of or within cilium organization	IMP IMP: Inferred from mutant phenotype	24585447	MGI
acts upstream of or within developmental pigmentation	IMP IMP: Inferred from mutant phenotype	10932191	MGI
involved in gene expression	IGI IGI: Inferred from genetic interaction	17490632	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	21211521	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11053430	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	10677508	MGI
acts upstream of or within neural crest cell differentiation	IMP IMP: Inferred from mutant phenotype	15384171	MGI
involved in neural plate development	IGI IGI: Inferred from genetic interaction	17490632	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	15384171	MGI
acts upstream of or within nodal signaling pathway	IMP IMP: Inferred from mutant phenotype	24585447	MGI
involved in paraxial mesoderm development	IGI IGI: Inferred from genetic interaction	17490632	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	20676059	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15465018	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11053430	MGI
involved in retinal ganglion cell axon guidance	IMP IMP: Inferred from mutant phenotype	13678579	MGI
involved in visual perception	IMP IMP: Inferred from mutant phenotype	13678579	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15207726	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11238441	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zinc finger protein ZIC 2

GENA 29	Zic family member 2 (odd-paired homolog, Drosophila)
kumba	odd-paired homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16074	ZIC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20352	Zic2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26861	Zic2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zic2	NCBI	NCBI:7546

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