Zic1 - zinc finger protein of the cerebellum 1 Gene

Mus musculus

Also known as ZIC; ZNF201

Gene ID: 22771 | Gene type: protein coding

About Zic1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including central nervous system development; positive regulation of protein import into nucleus; and regulation of smoothened signaling pathway. Acts upstream of or within adult walking behavior and central nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; future brain; metanephros; and visual system. Used to study Dandy-Walker syndrome and Joubert syndrome. Human ortholog(s) of this gene implicated in Dandy-Walker syndrome and craniosynostosis. Orthologous to human ZIC1 (Zic family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Zic1 Products(2)

mRNA	Protein	Name
NM_001376941.1	NP_001363870.1	zinc finger protein ZIC 1
NM_009573.4	NP_033599.2	zinc finger protein ZIC 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11053430	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11053430	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11053430	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18298960	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11238441	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	9412507	MGI
involved in brain development	IDA IDA: Inferred from direct assay	7931345	MGI
involved in cell cycle	IGI IGI: Inferred from genetic interaction	17507568	MGI
acts upstream of or within central nervous system development	IGI IGI: Inferred from genetic interaction	11756505	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	9412507	MGI
involved in forebrain development	IGI IGI: Inferred from genetic interaction	17507568	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	21211521	MGI
involved in hippocampus development	IGI IGI: Inferred from genetic interaction	17507568	MGI
involved in maintenance of cell number	IGI IGI: Inferred from genetic interaction	17507568	MGI
involved in olfactory bulb development	IGI IGI: Inferred from genetic interaction	17507568	MGI
involved in pattern specification process	IDA IDA: Inferred from direct assay	9070329	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11053430	MGI
involved in positive regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	11238441	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11053430	MGI
involved in regulation of smoothened signaling pathway	IPI IPI: Inferred from physical interaction	11238441	MGI
involved in spinal cord development	IMP IMP: Inferred from mutant phenotype	11944941	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15207726	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11238441	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zinc finger protein ZIC 1

Zic family member 1 (odd-paired homolog, Drosophila)

odd-paired homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16073	ZIC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174504	Human ZIC1 mRNA		/	Unkown
HY-RS21462	Zic1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27980	Zic1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zic1	NCBI	NCBI:7545

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