Wnt4 - wingless-type MMTV integration site family, member 4 Gene

Mus musculus

Also known as Wnt-4

Gene ID: 22417 | Gene type: protein coding

About Wnt4

Summary

Enables Frizzled binding activity and transcription corepressor activity. Involved in several processes, including paramesonephric duct development; positive regulation of cellular component biogenesis; and regulation of cellular biosynthetic process. Acts upstream of or within several processes, including animal organ development; negative regulation of signal transduction; and renal vesicle induction. Located in cell surface; extracellular matrix; and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Orthologous to human WNT4 (Wnt family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Wnt4 Products(1)

mRNA	Protein	Name
NM_009523.2	NP_033549.1	protein Wnt-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables frizzled binding	IPI IPI: Inferred from physical interaction	15265686	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9853965	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	12949260	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Sertoli cell differentiation	IMP IMP: Inferred from mutant phenotype	15581876	MGI
acts upstream of or within T cell differentiation in thymus	IDA IDA: Inferred from direct assay	11265645	MGI
acts upstream of or within anatomical structure development	IGI IGI: Inferred from genetic interaction	16818445	MGI
acts upstream of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	20454446	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	16054034	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IGI IGI: Inferred from genetic interaction	11948913	MGI
acts upstream of or within canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	11265645	MGI
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	15265686	MGI
acts upstream of or within canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	20454446	MGI
acts upstream of cell differentiation	IMP IMP: Inferred from mutant phenotype	15581876	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	18351662	MGI
acts upstream of or within cellular response to starvation	IEP IEP: Inferred from expression pattern	23260145	MGI
acts upstream of or within embryonic epithelial tube formation	IDA IDA: Inferred from direct assay	16546160	MGI
acts upstream of or within female gonad development	IMP IMP: Inferred from mutant phenotype	15162500	MGI
acts upstream of fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	16700629	MGI
acts upstream of or within gamete generation	IGI IGI: Inferred from genetic interaction	15162500	MGI
acts upstream of or within hormone metabolic process	IMP IMP: Inferred from mutant phenotype	12399432	MGI
acts upstream of or within immature T cell proliferation in thymus	IMP IMP: Inferred from mutant phenotype	18617424	MGI
acts upstream of or within kidney morphogenesis	IGI IGI: Inferred from genetic interaction	23362348	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	15581876	MGI
acts upstream of meiotic nuclear division	IGI IGI: Inferred from genetic interaction	20106871	MGI
acts upstream of or within mesenchymal to epithelial transition	IMP IMP: Inferred from mutant phenotype	7990960	MGI
acts upstream of or within mesonephric tubule development	IGI IGI: Inferred from genetic interaction	20040500	MGI
involved in mesonephros development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
acts upstream of or within metanephric nephron development	IMP IMP: Inferred from mutant phenotype	18346943	MGI
acts upstream of or within metanephric nephron morphogenesis	IMP IMP: Inferred from mutant phenotype	19830824	MGI
acts upstream of or within metanephric tubule formation	IMP IMP: Inferred from mutant phenotype	21350016	MGI
acts upstream of or within metanephros development	IMP IMP: Inferred from mutant phenotype	7990960	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12949260	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19301398	MGI
acts upstream of or within negative regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	20454446	MGI
acts upstream of or within negative regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	15581876	MGI
involved in negative regulation of cell migration	IGI IGI: Inferred from genetic interaction	23027131	MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	16700629	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	11948913	MGI
involved in negative regulation of testosterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	12949260	MGI
involved in negative regulation of wound healing	IGI IGI: Inferred from genetic interaction	23027131	MGI
acts upstream of or within nephron development	IMP IMP: Inferred from mutant phenotype	21295565	MGI
acts upstream of or within non-canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	18617424	MGI
acts upstream of or within oocyte development	IGI IGI: Inferred from genetic interaction	20454446	MGI
acts upstream of or within oocyte development	IMP IMP: Inferred from mutant phenotype	9989404	MGI
acts upstream of or within paramesonephric duct development	IMP IMP: Inferred from mutant phenotype	19830824	MGI
involved in paramesonephric duct development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
acts upstream of or within pericyte cell differentiation	IDA IDA: Inferred from direct assay	16546160	MGI
acts upstream of or within pericyte cell differentiation	IMP IMP: Inferred from mutant phenotype	16546160	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9356179	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11283799	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19301398	MGI
involved in positive regulation of GTPase activity	IGI IGI: Inferred from genetic interaction	23027131	MGI
involved in positive regulation of focal adhesion assembly	IGI IGI: Inferred from genetic interaction	23027131	MGI
acts upstream of or within positive regulation of meiotic nuclear division	IGI IGI: Inferred from genetic interaction	20106871	MGI
involved in positive regulation of stress fiber assembly	IGI IGI: Inferred from genetic interaction	23027131	MGI
acts upstream of or within regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	20106871	MGI
acts upstream of or within renal vesicle formation	IMP IMP: Inferred from mutant phenotype	16054034	MGI
acts upstream of or within renal vesicle induction	IDA IDA: Inferred from direct assay	11507767	MGI
acts upstream of or within sex differentiation	IMP IMP: Inferred from mutant phenotype	9989404	MGI
acts upstream of or within smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	16546160	MGI
acts upstream of or within smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	16546160	MGI
acts upstream of or within somatotropin secreting cell differentiation	IMP IMP: Inferred from mutant phenotype	18351662	MGI
acts upstream of or within tertiary branching involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	10733525	MGI
acts upstream of or within thyroid-stimulating hormone-secreting cell differentiation	IMP IMP: Inferred from mutant phenotype	18351662	MGI
acts upstream of or within tube morphogenesis	IMP IMP: Inferred from mutant phenotype	16546160	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	8167409	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	8167409	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	23027131	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein Wnt-4

signal molecule

wingless-related MMTV integration site 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15836	WNT4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17196	Wnt4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23648	Wnt4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wnt4	NCBI	NCBI:54361

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