Wnt3a - wingless-type MMTV integration site family, member 3A Gene

Mus musculus

Also known as vt; Wnt-3a

Gene ID: 22416 | Gene type: protein coding

About Wnt3a

Summary

Enables protein domain specific binding activity; signaling receptor binding activity; and transcription coactivator activity. Involved in several processes, including COP9 signalosome assembly; calcium ion transmembrane transport via low voltage-gated calcium channel; and nervous system development. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of macromolecule metabolic process. Located in cell surface and extracellular space. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; genitourinary system; and sensory organ. Orthologous to human WNT3A (Wnt family member 3A). [provided by Alliance of Genome Resources, Apr 2022]

Wnt3a Products(1)

mRNA	Protein	Name
NM_009522.3	NP_033548.1	protein Wnt-3a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables frizzled binding	IDA IDA: Inferred from direct assay	19910923	MGI
enables frizzled binding	IPI IPI: Inferred from physical interaction	18606138	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	31036956	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10866835	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15454084	MGI
enables receptor ligand activity	IDA IDA: Inferred from direct assay	10557084	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	17994217	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell proliferation	IDA IDA: Inferred from direct assay	10933391	MGI
involved in COP9 signalosome assembly	IDA IDA: Inferred from direct assay	17569865	MGI
involved in Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16115200	MGI
acts upstream of or within Wnt signaling pathway involved in forebrain neuroblast division	IMP IMP: Inferred from mutant phenotype	10631167	MGI
acts upstream of or within anterior/posterior pattern specification	IDA IDA: Inferred from direct assay	15148409	MGI
acts upstream of or within axis elongation involved in somitogenesis	IGI IGI: Inferred from genetic interaction	11029008	MGI
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	18716223	MGI
acts upstream of or within axonogenesis	IDA IDA: Inferred from direct assay	15454084	MGI
acts upstream of or within axonogenesis	IGI IGI: Inferred from genetic interaction	15454084	MGI
involved in calcium ion transmembrane transport via low voltage-gated calcium channel	IDA IDA: Inferred from direct assay	20371816	MGI
acts upstream of or within canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	31222549	MGI
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	10557084	MGI
involved in canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	10409711	MGI
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19701191	MGI
acts upstream of or within cardiac muscle cell fate commitment	IGI IGI: Inferred from genetic interaction	21554246	MGI
involved in cell proliferation in forebrain	IDA IDA: Inferred from direct assay	12843296	MGI
involved in cell proliferation in midbrain	IDA IDA: Inferred from direct assay	14557550	MGI
acts upstream of cytokine production	IDA IDA: Inferred from direct assay	23677472	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	16291790	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IMP IMP: Inferred from mutant phenotype	8299937	MGI
acts upstream of or within extracellular matrix organization	IDA IDA: Inferred from direct assay	17943183	MGI
acts upstream of fat cell differentiation	IDA IDA: Inferred from direct assay	17888405	MGI
acts upstream of fat cell differentiation	IGI IGI: Inferred from genetic interaction	17888405	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	16291790	MGI
acts upstream of or within hemopoiesis	IDA IDA: Inferred from direct assay	12717450	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	10631167	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	4819561	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	15961523	MGI
acts upstream of or within mammary gland development	IDA IDA: Inferred from direct assay	15342465	MGI
acts upstream of or within mesoderm development	IMP IMP: Inferred from mutant phenotype	8299937	MGI
involved in midbrain development	IDA IDA: Inferred from direct assay	14557550	MGI
involved in modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	16501258	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	16501258	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	16501258	MGI
acts upstream of or within myoblast differentiation	IGI IGI: Inferred from genetic interaction	19699733	MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	18716223	MGI
involved in negative regulation of dopaminergic neuron differentiation	IDA IDA: Inferred from direct assay	14557550	MGI
acts upstream of or within negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	15796911	MGI
acts upstream of or within negative regulation of fat cell differentiation	IGI IGI: Inferred from genetic interaction	17888405	MGI
involved in negative regulation of neurogenesis	IDA IDA: Inferred from direct assay	12843296	MGI
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	21539518	MGI
involved in neurogenesis	IDA IDA: Inferred from direct assay	14557550	MGI
involved in non-canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17244647	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: Inferred from genetic interaction	16581771	MGI
acts upstream of or within paraxial mesodermal cell fate commitment	IMP IMP: Inferred from mutant phenotype	9126297	MGI
acts upstream of or within platelet activation	IDA IDA: Inferred from direct assay	19901330	MGI
acts upstream of or within platelet aggregation	IDA IDA: Inferred from direct assay	19901330	MGI
acts upstream of or within positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	10933391	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18929644	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9356179	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17994217	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	18155657	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19690384	MGI
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17994217	MGI
acts upstream of or within positive regulation of cell-cell adhesion mediated by cadherin	IDA IDA: Inferred from direct assay	10893270	MGI
acts upstream of or within positive regulation of collateral sprouting in absence of injury	IDA IDA: Inferred from direct assay	18716223	MGI
acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	17251350	MGI
acts upstream of or within positive regulation of cytokine production	IDA IDA: Inferred from direct assay	23677472	MGI
acts upstream of or within positive regulation of hepatocyte proliferation	IDA IDA: Inferred from direct assay	23740243	MGI
acts upstream of or within positive regulation of neural precursor cell proliferation	IDA IDA: Inferred from direct assay	19896444	MGI
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	22899650	MGI
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	17027228	MGI
acts upstream of or within positive regulation of protein tyrosine kinase activity	IGI IGI: Inferred from genetic interaction	19920076	MGI
involved in positive regulation of skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	11856745	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23740243	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20371816	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19699733	MGI
acts upstream of or within positive effect positive regulation of type B pancreatic cell proliferation	IDA IDA: Inferred from direct assay	17994217	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	8299937	MGI
acts upstream of or within protein localization	IDA IDA: Inferred from direct assay	17606995	MGI
acts upstream of or within regulation of RNA biosynthetic process	IDA IDA: Inferred from direct assay	22665494	MGI
acts upstream of or within regulation of axonogenesis	IGI IGI: Inferred from genetic interaction	18716223	MGI
acts upstream of or within regulation of cell differentiation	IDA IDA: Inferred from direct assay	12717450	MGI
acts upstream of or within regulation of microtubule cytoskeleton organization	IGI IGI: Inferred from genetic interaction	18716223	MGI
involved in regulation of postsynapse to nucleus signaling pathway	EXP EXP: Inferred from Experiment	16501258	MGI
involved in regulation of postsynapse to nucleus signaling pathway	IDA IDA: Inferred from direct assay	16501258	MGI
acts upstream of or within skeletal muscle cell differentiation	IGI IGI: Inferred from genetic interaction	19699733	MGI
acts upstream of or within somatic stem cell division	IDA IDA: Inferred from direct assay	12717450	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	8299937	MGI
acts upstream of or within spinal cord association neuron differentiation	IDA IDA: Inferred from direct assay	11877374	MGI
acts upstream of or within spinal cord association neuron differentiation	IGI IGI: Inferred from genetic interaction	11877374	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19699733	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	8167409	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	12897152	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	16501258	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16501258	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16501258	MGI
is active in synapse	IDA IDA: Inferred from direct assay	16501258	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein Wnt-3a

vestigial tail

wingless-related MMTV integration site 3A

Wnt3a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Wnt3a	P27467	AFM	Homo sapiens	P43652	GMS	26902720
Intra	Wnt3a	P27467	AFM	Homo sapiens	P43652	Anti Tag CoIP	26902720
Cross	Wnt3a	P27467	LRP6	Homo sapiens	O75581	Comig Non-Denat Gel	23791946
Intra	Wnt3a	P27467	Fzd8	Mus musculus	Q61091	Pull Down	31036956
Intra	Wnt3a	P27467	Fzd8	Mus musculus	Q61091	Anti Tag CoIP	31036956
Cross	Wnt3a	P27467	WIF1	Homo sapiens	Q9Y5W5	Competition Binding	22986341
Cross	Wnt3a	P27467	TRABD2B	Homo sapiens	A6NFA1	Protease Assay	22726442
Intra	Wnt3a	P27467	Ptpro	Mus musculus	E9Q612	Anti Tag CoIP	20804755
Intra	Wnt3a	P27467	Ptpro	Mus musculus	E9Q612	Crosslink	20804755
Cross	Wnt3a	P27467	AFM	Bos taurus	G3MYZ3	Anti Tag CoIP	26902720

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129079A	TFMB-(S)-2-HG	Inhibitor	99.79%	Unkown
HY-153855	Zamaporvint	Inhibitor	99.76%	Unkown
HY-122832	ABC99	Inhibitor	98.48%	Unkown
HY-160709	Wnt/β-catenin-IN-2	Inhibitor	/	Unkown
HY-P10204	FZD7 antagonist 1		/	Unkown
HY-RS15835	WNT3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16706	Wnt3a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23141	Wnt3a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wnt3a	NCBI	NCBI:89780

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