Wfs1 - wolframin ER transmembrane glycoprotein Gene

Mus musculus

Also known as wolframin

Gene ID: 22393 | Gene type: protein coding

About Wfs1

Summary

Enables ATPase binding activity. Involved in several processes, including negative regulation of apoptotic process; protein stabilization; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum. Is expressed in several structures, including brain; craniocervical region bone; diaphragm; stomach; and vertebral axis musculature. Used to study Wolfram syndrome 1. Human ortholog(s) of this gene implicated in Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER Transmembrane Glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Wfs1 Products(1)

mRNA	Protein	Name
NM_011716.2	NP_035846.1	wolframin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IDA IDA: Inferred from direct assay	17947299	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	20160352	MGI
involved in endoplasmic reticulum unfolded protein response	IMP IMP: Inferred from mutant phenotype	16571599	MGI
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	16571599	MGI
involved in negative regulation of translation	IMP IMP: Inferred from mutant phenotype	19911006	MGI
involved in negative regulation of type B pancreatic cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16087305	MGI
involved in positive regulation of ERAD pathway	IMP IMP: Inferred from mutant phenotype	19911006	MGI
involved in positive regulation of growth	IMP IMP: Inferred from mutant phenotype	19293327	MGI
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	20160352	MGI
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	20160352	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	15994758	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16087305	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

wolframin

Wolfram syndrome 1 homolog

Wolfram syndrome 1 protein homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137605	WSF1-IN-1	Inhibitor	99.91%	Unkown
HY-RS15813	WFS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18644	Wfs1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25129	Wfs1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wfs1	NCBI	NCBI:7466

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