2. Gene
  3. Ubb - ubiquitin B Gene

Ubb - ubiquitin B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ubc; Ubb2; Uba52; Rps27a

Gene ID: 22187 | Gene type: protein coding

About Ubb

Summary

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of four direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Pseudogenes of this gene are located on chromosomes 3 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Ubb Products(4)

mRNA Protein Name
NM_001313984.2 NP_001300913.1 polyubiquitin-B precursor
NM_011664.5 NP_035794.1 polyubiquitin-B precursor
NM_001313984.2 NP_001300913.1 polyubiquitin-B precursor
NM_011664.5 NP_035794.1 polyubiquitin-B precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within adipose tissue development IMP
IMP: Inferred from mutant phenotype
18299572 MGI
acts upstream of or within energy homeostasis IMP
IMP: Inferred from mutant phenotype
18299572 MGI
acts upstream of or within fat pad development IMP
IMP: Inferred from mutant phenotype
18299572 MGI
acts upstream of or within female gonad development IMP
IMP: Inferred from mutant phenotype
18070917 MGI
acts upstream of or within female meiosis I IMP
IMP: Inferred from mutant phenotype
18070917 MGI
acts upstream of or within hypothalamus gonadotrophin-releasing hormone neuron development IMP
IMP: Inferred from mutant phenotype
18299572 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
18070917 MGI
acts upstream of or within male meiosis I IMP
IMP: Inferred from mutant phenotype
18070917 MGI
acts upstream of or within seminiferous tubule development IMP
IMP: Inferred from mutant phenotype
18070917 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polyubiquitin-B

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15333 UBB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18903 Ubb Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25394 Ubb Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ubb NCBI NCBI:7314