2. Gene
  3. Tubb4a - tubulin, beta 4A class IVA Gene

Tubb4a - tubulin, beta 4A class IVA Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tubb; Tubb4; M(beta)4

Gene ID: 22153 | Gene type: protein coding

About Tubb4a

Summary

Predicted to enable GTP binding activity and calcium ion binding activity. Predicted to be a structural constituent of Cytoskeleton. Predicted to be involved in microtubule Cytoskeleton organization; mitotic cell cycle; and negative regulation of microtubule polymerization. Predicted to act upstream of or within cell projection organization. Located in several cellular components, including internode region of axon; myelin sheath; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study hypomyelinating leukodystrophy 6. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 6 and torsion dystonia 4. Orthologous to human TUBB4A (tubulin beta 4A class IVa). [provided by Alliance of Genome Resources, Apr 2022]

Tubb4a Products(1)

mRNA Protein Name
NM_009451.4 NP_033477.2 tubulin beta-4A chain
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in cell projection IDA
IDA: Inferred from direct assay
16421295 MGI
located in cilium IDA
IDA: Inferred from direct assay
11724907 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16574095 MGI
located in internode region of axon IDA
IDA: Inferred from direct assay
16421295 MGI
located in myelin sheath IDA
IDA: Inferred from direct assay
16421295 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
16421295 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tubulin beta-4A chain

tubulin beta-4 chain

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15255 TUBB4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20612 Tubb4a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27120 Tubb4a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tubb4a NCBI NCBI:10382