Tsc2 - TSC complex subunit 2 Gene

Mus musculus

Also known as Tcs2; Nafld

Gene ID: 22084 | Gene type: protein coding

About Tsc2

Summary

Enables 14-3-3 protein binding activity. Involved in several processes, including anoikis; chemical synaptic transmission; and negative regulation of TORC1 signaling. Acts upstream of or within several processes, including intracellular protein transport; intracellular signal transduction; and negative regulation of intracellular signal transduction. Located in cytoplasm. Is active in synapse. Is expressed in several structures, including aorta; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Used to study autism spectrum disorder; tuberous sclerosis; and uterine fibroid. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Tsc2 Products(24)

mRNA	Protein	Name
NM_001039363.3	NP_001034452.1	tuberin isoform 2
NM_001286713.2	NP_001273642.1	tuberin isoform 3
NM_001286714.2	NP_001273643.1	tuberin isoform 1
NM_001286716.2	NP_001273645.1	tuberin isoform 2
NM_001286718.2	NP_001273647.1	tuberin isoform 4
NM_001286720.2	NP_001273649.1	tuberin isoform 5
NM_001403402.1	NP_001390331.1	tuberin isoform 16
NM_001403403.1	NP_001390332.1	tuberin isoform 17
NM_001403404.1	NP_001390333.1	tuberin isoform 17
NM_001403405.1	NP_001390334.1	tuberin isoform 16
NM_001403406.1	NP_001390335.1	tuberin isoform 15
NM_001403407.1	NP_001390336.1	tuberin isoform 14
NM_001403408.1	NP_001390337.1	tuberin isoform 13
NM_001403409.1	NP_001390338.1	tuberin isoform 12
NM_001403410.1	NP_001390339.1	tuberin isoform 11
NM_001403411.1	NP_001390340.1	tuberin isoform 11
NM_001403412.1	NP_001390341.1	tuberin isoform 10
NM_001403413.1	NP_001390342.1	tuberin isoform 9
NM_001403414.1	NP_001390343.1	tuberin isoform 6
NM_001403415.1	NP_001390344.1	tuberin isoform 8
NM_001403416.1	NP_001390345.1	tuberin isoform 7
NM_001403417.1	NP_001390346.1	tuberin isoform 4
NM_001403418.1	NP_001390347.1	tuberin isoform 6
NM_011647.4	NP_035777.2	tuberin isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 14-3-3 protein binding	IDA IDA: Inferred from direct assay	18198340	MGI
enables GTPase activator activity	IDA IDA: Inferred from direct assay	12820960	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11741832	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell proliferation	IGI IGI: Inferred from genetic interaction	16027169	MGI
acts upstream of or within D-glucose import	IMP IMP: Inferred from mutant phenotype	18511518	MGI
acts upstream of T cell proliferation	IGI IGI: Inferred from genetic interaction	16027169	MGI
involved in anoikis	IMP IMP: Inferred from mutant phenotype	23778976	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	16027168	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10096549	MGI
acts upstream of or within cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	18511518	MGI
involved in cellular response to starvation	IDA IDA: Inferred from direct assay	24529379	MGI
involved in excitatory chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	30679017	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	10096549	MGI
involved in inhibitory chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	30679017	MGI
acts upstream of or within negative regulation of B cell proliferation	IGI IGI: Inferred from genetic interaction	16027169	MGI
acts upstream of or within negative regulation of T cell proliferation	IGI IGI: Inferred from genetic interaction	16027169	MGI
involved in negative regulation of TOR signaling	IGI IGI: Inferred from genetic interaction	23778976	MGI
acts upstream of or within negative regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	18198340	MGI
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	12820960	MGI
involved in negative regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	23878245	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	16027168	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10096549	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	16027169	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	16027169	MGI
acts upstream of or within negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	15249583	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	10096549	MGI
acts upstream of or within positive chemotaxis	IMP IMP: Inferred from mutant phenotype	15249583	MGI
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	23878245	MGI
acts upstream of or within positive regulation of insulin receptor signaling pathway	IGI IGI: Inferred from genetic interaction	15249583	MGI
acts upstream of or within positive regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15249583	MGI
acts upstream of or within positive regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	20453062	MGI
involved in positive regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	23778976	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23858058	MGI
acts upstream of or within protein import into nucleus	IMP IMP: Inferred from mutant phenotype	10827137	MGI
acts upstream of or within protein localization	IDA IDA: Inferred from direct assay	11741832	MGI
acts upstream of or within protein transport into plasma membrane raft	IMP IMP: Inferred from mutant phenotype	18511518	MGI
acts upstream of or within regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	10827137	MGI
acts upstream of or within regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12403809	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	18198340	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23858058	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of TSC1-TSC2 complex	IDA IDA: Inferred from direct assay	12820960	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11741832	MGI
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	24529379	MGI
is active in synapse	EXP EXP: Inferred from Experiment	16452087	MGI
is active in synapse	IDA IDA: Inferred from direct assay	16452087	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tuberin

tuberous sclerosis 2 protein homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134904	RMC-6272	Inhibitor	95.54%	Unkown
HY-150229	306-N16B		99.27%	Unkown
HY-134922	NS1-IN-1	Inhibitor	/	Unkown
HY-RS15132	TSC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-155475	mTORC1-IN-2	Inhibitor	/	Unkown
HY-RS17096	Tsc2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23540	Tsc2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tsc2	NCBI	NCBI:7249

Name
Email *

	Sorry, but the email address you supplied was invalid.