2. Gene
  3. Trpc6 - transient receptor potential cation channel, subfamily C, member 6 Gene

Trpc6 - transient receptor potential cation channel, subfamily C, member 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TRP-6; Trrp6; mtrp6; LLHWJM002; LLHWJM003; LLHWJM004

Gene ID: 22068 | Gene type: protein coding

About Trpc6

Summary

Enables store-operated Calcium Channel activity. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Located in plasma membrane and slit diaphragm. Is expressed in several structures, including gut; limb; liver; nervous system; and reproductive system. Used to study focal segmental glomerulosclerosis 2. Human ortholog(s) of this gene implicated in chronic fatigue syndrome; focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6). [provided by Alliance of Genome Resources, Apr 2022]

Trpc6 Products(3)

mRNA Protein Name
NM_001282086.1 NP_001269015.1 short transient receptor potential channel 6 isoform 2
NM_001282087.1 NP_001269016.1 short transient receptor potential channel 6 isoform 3
NM_013838.2 NP_038866.2 short transient receptor potential channel 6 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables monoatomic ion channel activity IDA
IDA: Inferred from direct assay
15194687 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15924139 MGI
enables store-operated calcium channel activity IDA
IDA: Inferred from direct assay
8646775 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
9368034 MGI
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
15924139 MGI
located in slit diaphragm IDA
IDA: Inferred from direct assay
15924139 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

short transient receptor potential channel 6

calcium entry channel

transient receptor protein 6

Related Agents

Pre-clinical Phase
Bioactive Molecules (31)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111925 BI-749327 Antagonist 99.91% Unkown
HY-111098 GSK1702934A Agonist 99.11% Unkown
HY-101507 Zerencotrep Inhibitor 99.47% Unkown
HY-116330A Hyperforin dicyclohexylammonium salt 99.52% Unkown
HY-12949 ML204 Inhibitor 98.45% Unkown
HY-15699 SAR7334 Inhibitor 99.82% Unkown
HY-108457 9-Phenanthrol Inhibitor 99.61% Unkown
HY-122051 AC1903 Inhibitor 99.80% Unkown
HY-15699A SAR7334 hydrochloride Inhibitor ≥98.0% Unkown
HY-101795 Larixyl acetate Inhibitor 99.46% Unkown
HY-12949A ML204 hydrochloride Inhibitor 99.74% Unkown
HY-136190 TRPC6-PAM-C20 Agonist 99.78% Unkown
HY-N10756 Hyp9 Agonist 99.90% Unkown
HY-W744699 Larixol Inhibitor 95.52% Unkown
HY-148129 Apecotrep Inhibitor 99.62% Unkown
HY-101547 TRPC6-IN-1 Inhibitor 99.71% Unkown
HY-111527 PPZ2 99.92% Unkown
HY-133012 GFB-8438 Inhibitor 99.74% Unkown
HY-112298 DS88790512 Inhibitor / Unkown
HY-116330 Hyperforin / Unkown
HY-120818 TRPC3/6-IN-3 / Unkown
HY-121519 GSK2332255B Antagonist / Unkown
HY-145151 TRPC6-IN-2 / Unkown
HY-153455 TRPC3/6-IN-2 Inhibitor / Unkown
HY-172600 TRPC6 antagonist-1 Antagonist / Unkown
HY-RS15109 TRPC6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W707161 4-Methyl-2-(1-piperidinyl)-quinoline-d10 / Unkown
HY-W745090 Isomaltulose monohydrate / Unkown
HY-147357 TRPC3/6-IN-1 Inhibitor / Unkown
HY-RS16595 Trpc6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23029 Trpc6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpc6 NCBI NCBI:7225