2. Gene
  3. Trpc4 - transient receptor potential cation channel, subfamily C, member 4 Gene

Trpc4 - transient receptor potential cation channel, subfamily C, member 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CCE1; Trp4; Trrp4; STRPC4

Gene ID: 22066 | Gene type: protein coding

About Trpc4

Summary

Enables inositol 1,4,5 trisphosphate binding activity and store-operated Calcium Channel activity. Acts upstream of or within gamma-aminobutyric acid secretion and oligodendrocyte differentiation. Located in caveola. Part of protein-containing complex. Is expressed in several structures, including brain; cochlea; ganglia; genitourinary system; and liver. Orthologous to human TRPC4 (transient receptor potential cation channel subfamily C member 4). [provided by Alliance of Genome Resources, Apr 2022]

Trpc4 Products(3)

mRNA Protein Name
NM_001253682.1 NP_001240611.1 short transient receptor potential channel 4 isoform 2
NM_001253683.1 NP_001240612.1 short transient receptor potential channel 4 isoform 3
NM_016984.3 NP_058680.1 short transient receptor potential channel 4 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables inositol 1,4,5 trisphosphate binding IDA
IDA: Inferred from direct assay
14505576 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17416589 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within gamma-aminobutyric acid secretion IMP
IMP: Inferred from mutant phenotype
14668438 MGI
acts upstream of or within oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
19139271 MGI
Cellular Component GO Annotation Evidence Reference Source
located in caveola IDA
IDA: Inferred from direct assay
11897792 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
17416589 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10998353 MGI
part of protein-containing complex IPI
IPI: Inferred from physical interaction
17416589 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

short transient receptor potential channel 4

capacitative calcium entry channel Trp4

putative capacitative calcium entry channel

receptor-activated cation channel TRP4

transient receptor protein 4

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-162584 TRPC4/5-IN-2 Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101507 Zerencotrep Inhibitor 99.47% Unkown
HY-12949 ML204 Inhibitor 98.45% Unkown
HY-133168 Englerin A Activator 99.50% Unkown
HY-112302 HC-070 Antagonist 99.73% Unkown
HY-122051 AC1903 Inhibitor 99.80% Unkown
HY-12949A ML204 hydrochloride Inhibitor 99.74% Unkown
HY-132813 Evifacotrep Antagonist 99.65% Unkown
HY-144429 TRPC5-IN-4 Inhibitor / Unkown
HY-146155 TRPC4/5-IN-1 Inhibitor / Unkown
HY-162090 TRPC antagonist 1 Antagonist / Unkown
HY-173024 TRPC4/5-IN-3 Inhibitor / Unkown
HY-RS15106 TRPC4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS15107 TRPC4AP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-110379 M084 hydrochloride Inhibitor / Unkown
HY-RS16978 Trpc4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23421 Trpc4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpc4 NCBI NCBI:7223