Plscr1 - phospholipid scramblase 1 Gene

Mus musculus

Also known as Nor1; Tra1; Tra1a; Tra1b; Tras1; Tras2; MmTRA1a; MmTRA1b

Gene ID: 22038 | Gene type: protein coding

About Plscr1

Summary

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of viral genome replication; phosphatidylserine biosynthetic process; and response to interferon-alpha. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; phosphatidylserine exposure on apoptotic cell surface; and positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Located in cytosol; nucleus; and plasma membrane. Is expressed in hindgut; midgut; renal calyx; and renal pelvis. Orthologous to human PLSCR1 (phospholipid scramblase 1). [provided by Alliance of Genome Resources, Apr 2022]

Plscr1 Products(2)

mRNA	Protein	Name
NM_001410453.1	NP_001397382.1	phospholipid scramblase 1
NM_011636.3	NP_035766.2	phospholipid scramblase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32110987	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in acute-phase response	IEP IEP: Inferred from expression pattern	17590392	MGI
involved in cellular response to cytokine stimulus	IEP IEP: Inferred from expression pattern	17590392	MGI
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	17590392	MGI
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	15308695	MGI
involved in intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	15863367	MGI
acts upstream of or within myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	15328404	MGI
acts upstream of or within negative regulation of protein binding	IDA IDA: Inferred from direct assay	16611984	MGI
involved in negative regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	15308695	MGI
involved in phosphatidylserine biosynthetic process	IDA IDA: Inferred from direct assay	12509439	MGI
acts upstream of or within phosphatidylserine exposure on apoptotic cell surface	IDA IDA: Inferred from direct assay	12509439	MGI
involved in phosphatidylserine exposure on apoptotic cell surface	IMP IMP: Inferred from mutant phenotype	32110987	MGI
involved in plasma membrane phospholipid scrambling	IDA IDA: Inferred from direct assay	12509439	MGI
acts upstream of or within positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	16611984	MGI
involved in positive regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	15308695	MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	12509439	MGI
involved in response to interferon-alpha	IMP IMP: Inferred from mutant phenotype	15308695	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	17590392	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17590392	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12509439	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phospholipid scramblase 1

PL scramblase 1	ca(2+)-dependent phospholipid scramblase 1
mg(2+)-dependent nuclease	transplantability-associated protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10741	PLSCR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18201	Plscr1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24677	Plscr1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plscr1	NCBI	NCBI:5359

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