Tph1 - tryptophan hydroxylase 1 Gene

Mus musculus

Also known as Tph

Gene ID: 21990 | Gene type: protein coding

About Tph1

Summary

This gene encodes a member of the biopterin-dependent aromatic amino acid hydroxylase family. The encoded protein is one of two Tryptophan Hydroxylase enzymes that catalyze the first and rate limiting step in the biosynthesis of the hormone and neurotransmitter, serotonin. This gene is expressed in peripheral organs, while Tryptophan Hydroxylase 2 is expressed in neurons. The encoded protein is involved in the development of hypoxia-induced elevations in pulmonary pressures and pulmonary vascular remodeling, and has also been implicated as a regulator of immune tolerance. Disruption of this gene is associated with cardiac dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Tph1 Products(3)

mRNA	Protein	Name
NM_001136084.2	NP_001129556.1	tryptophan 5-hydroxylase 1 isoform 1
NM_001276372.1	NP_001263301.1	tryptophan 5-hydroxylase 1 isoform 2
NM_009414.3	NP_033440.1	tryptophan 5-hydroxylase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables tryptophan 5-monooxygenase activity	IDA IDA: Inferred from direct assay	2110547	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within bone remodeling	IGI IGI: Inferred from genetic interaction	19041748	MGI
acts upstream of or within mammary gland alveolus development	IMP IMP: Inferred from mutant phenotype	14960274	MGI
involved in platelet degranulation	IMP IMP: Inferred from mutant phenotype	14697203	MGI
acts upstream of or within positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	20719859	MGI
involved in regulation of hemostasis	IMP IMP: Inferred from mutant phenotype	14697203	MGI
involved in serotonin biosynthetic process	IMP IMP: Inferred from mutant phenotype	14697203	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23500099	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tryptophan 5-hydroxylase 1

tryptophan 5-monooxygenase 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101124	Rodatristat ethyl	Inhibitor	≥98.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W019599	4-Chloro-L-phenylalanine	Inhibitor	≥98.0%	Unkown
HY-120083	Rodatristat	Inhibitor	98.41%	Unkown
HY-RS14932	TPH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-156093	TPH1-IN-1	Inhibitor	/	Unkown
HY-157014	TPT-004	Inhibitor	99.90%	Unkown
HY-RS17127	Tph1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23572	Tph1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tph1	NCBI	NCBI:7166

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