Thbs1 - thrombospondin 1 Gene

Mus musculus

Also known as TSP1; TSP-1; tbsp1; Thbs-1

Gene ID: 21825 | Gene type: protein coding

About Thbs1

Summary

The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V Collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Thbs1 Products(2)

mRNA	Protein	Name
NM_001313914.1	NP_001300843.1	thrombospondin-1 isoform 2 precursor
NM_011580.4	NP_035710.2	thrombospondin-1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables extracellular matrix binding	IDA IDA: Inferred from direct assay	18757743	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22682248	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to pain	IMP IMP: Inferred from mutant phenotype	22745497	MGI
acts upstream of or within blood vessel morphogenesis	IGI IGI: Inferred from genetic interaction	20026598	MGI
acts upstream of or within cellular response to nitric oxide	IMP IMP: Inferred from mutant phenotype	16150726	MGI
acts upstream of or within endocardial cushion development	IGI IGI: Inferred from genetic interaction	20026598	MGI
acts upstream of or within growth plate cartilage development	IGI IGI: Inferred from genetic interaction	18467703	MGI
acts upstream of or within growth plate cartilage development	IMP IMP: Inferred from mutant phenotype	18467703	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	15963261	MGI
acts upstream of or within monocyte aggregation	IMP IMP: Inferred from mutant phenotype	28228282	MGI
acts upstream of or within negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	12498716	MGI
acts upstream of or within negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	16150726	MGI
acts upstream of or within negative regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16150726	MGI
acts upstream of or within outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	20026598	MGI
acts upstream of or within positive regulation of cell-substrate adhesion	IDA IDA: Inferred from direct assay	18757743	MGI
involved in positive regulation of macrophage chemotaxis	IMP IMP: Inferred from mutant phenotype	18757424	MGI
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9657149	MGI
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	22682248	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	22682248	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	18285447	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	12498716	MGI
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	22682248	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

thrombospondin-1

glycoprotein G

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14479	THBS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16903	Thbs1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23345	Thbs1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Thbs1	NCBI	NCBI:7057

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