Flvcr2 - feline leukemia virus subgroup C cellular receptor 2 Gene

Mus musculus

Also known as CCT; Mfsd7c

Gene ID: 217721 | Gene type: protein coding

About Flvcr2

Summary

Predicted to enable heme binding activity and heme transmembrane transporter activity. Predicted to be involved in heme export. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system and yolk sac. Used to study proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Human ortholog(s) of this gene implicated in proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Orthologous to human FLVCR2 (FLVCR heme transporter 2). [provided by Alliance of Genome Resources, Apr 2022]

Flvcr2 Products(1)

mRNA	Protein	Name
NM_145447.2	NP_663422.1	feline leukemia virus subgroup C receptor-related protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables choline binding	IDA IDA: Inferred from direct assay	38693257	MGI
enables choline transmembrane transporter activity	IDA IDA: Inferred from direct assay	38302740	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	32973183	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	32369453	MGI
involved in choline transport	IDA IDA: Inferred from direct assay	38693257	MGI
acts upstream of or within choline transport	IMP IMP: Inferred from mutant phenotype	38693257	MGI
acts upstream of or within endothelial tip cell fate specification	IMP IMP: Inferred from mutant phenotype	32369453	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	32369453	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	32369453	MGI
acts upstream of or within sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	32369453	MGI
involved in transport across blood-brain barrier	IDA IDA: Inferred from direct assay	38302740	MGI
acts upstream of or within transport across blood-brain barrier	IMP IMP: Inferred from mutant phenotype	38693257	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	38302740	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

feline leukemia virus subgroup C receptor-related protein 2

calcium-chelate transporter	feline leukemia virus subgroup C cellular receptor family, member 2
major facilitator superfamily domain containing 7C

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04998	FLVCR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21132	Flvcr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27650	Flvcr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Flvcr2	NCBI	NCBI:55640

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