2. Gene
  3. Kdm6b - KDM1 lysine (K)-specific demethylase 6B Gene

Kdm6b - KDM1 lysine (K)-specific demethylase 6B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Jmjd3; 1700064E03Rik

Gene ID: 216850 | Gene type: protein coding

About Kdm6b

Summary

Enables beta-catenin binding activity; histone H3-tri/di-methyl-lysine-27 demethylase activity; and sequence-specific DNA binding activity. Involved in several processes, including histone H3-K27 demethylation; mesodermal cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; histone demethylation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including brain; gut; liver; metanephros; and olfactory epithelium. Orthologous to human KDM6B (lysine demethylase 6B). [provided by Alliance of Genome Resources, Apr 2022]

Kdm6b Products(1)

mRNA Protein Name
NM_001017426.2 NP_001017426.1 lysine-specific demethylase 6B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
23856522 MGI
enables histone H3K27me2/H3K27me3 demethylase activity IDA
IDA: Inferred from direct assay
23856522 MGI
enables histone H3K27me2/H3K27me3 demethylase activity IMP
IMP: Inferred from mutant phenotype
17928865 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21095589 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17928865 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
23856522 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
18716661 MGI
acts upstream of or within cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
20808772 MGI
involved in chromatin remodeling IMP
IMP: Inferred from mutant phenotype
21095589 MGI
involved in endothelial cell differentiation IMP
IMP: Inferred from mutant phenotype
23856522 MGI
involved in mesodermal cell differentiation IMP
IMP: Inferred from mutant phenotype
23856522 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
26625958 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17928865 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17928865 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23856522 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18716661 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
23856522 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase 6B

[histone H3]-trimethyl-L-lysine(27) demethylase 6B

jmjC domain-containing protein 3

jumonji domain containing 3

jumonji domain-containing protein 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15648B GSK-J4 99.64% Unkown
HY-12304 IOX1 Inhibitor 99.89% Unkown
HY-15648 GSK-J1 Inhibitor 99.94% Unkown
HY-15648F GSK-J4 hydrochloride Inhibitor 99.01% Unkown
HY-100764 YUKA1 Inhibitor 99.15% Unkown
HY-15648A GSK-J2 Control 99.75% Unkown
HY-N6896 Isoviolanthin Inhibitor 99.66% Unkown
HY-RS07223 KDM6B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-15648D GSK-J1 lithium salt Inhibitor 98.33% Unkown
HY-15648G GSK-J1 sodium Inhibitor / Unkown
HY-15648I GSK-J2 sodium Inhibitor / Unkown
HY-RS17203 Kdm6b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23655 Kdm6b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm6b NCBI NCBI:23135