2. Gene
  3. Tead2 - TEA domain family member 2 Gene

Tead2 - TEA domain family member 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ETF; Etdf; TEF4; TEF-4; ETEF-1; TEAD-2

Gene ID: 21677 | Gene type: protein coding

About Tead2

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of cell death. Acts upstream of or within several processes, including cellular response to retinoic acid; mesenchyme development; and tube morphogenesis. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and limb bud. Orthologous to human TEAD2 (TEA domain transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tead2 Products(5)

mRNA Protein Name
NM_001285498.2 NP_001272427.1 transcriptional enhancer factor TEF-4 isoform a
NM_001285500.2 NP_001272429.1 transcriptional enhancer factor TEF-4 isoform b
NM_001379272.1 NP_001366201.1 transcriptional enhancer factor TEF-4 isoform a
NM_001379273.1 NP_001366202.1 transcriptional enhancer factor TEF-4 isoform a
NM_011565.3 NP_035695.1 transcriptional enhancer factor TEF-4 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
7629195 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
14736747 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16207754 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10934189 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to retinoic acid IDA
IDA: Inferred from direct assay
21385842 MGI
acts upstream of or within embryonic heart tube morphogenesis IGI
IGI: Inferred from genetic interaction
18332127 MGI
acts upstream of or within lateral mesoderm development IGI
IGI: Inferred from genetic interaction
18332127 MGI
involved in mesenchyme development IGI
IGI: Inferred from genetic interaction
20596238 MGI
involved in nervous system development IGI
IGI: Inferred from genetic interaction
20596238 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
17868131 MGI
acts upstream of or within notochord development IGI
IGI: Inferred from genetic interaction
18332127 MGI
acts upstream of or within paraxial mesoderm development IGI
IGI: Inferred from genetic interaction
18332127 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9502435 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16207754 MGI
acts upstream of or within regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
21385842 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14736747 MGI
acts upstream of or within vasculogenesis IGI
IGI: Inferred from genetic interaction
18332127 MGI
Cellular Component GO Annotation Evidence Reference Source
part of transcription regulator complex IDA
IDA: Inferred from direct assay
16207754 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcriptional enhancer factor TEF-4

embryonic TEA domain-containing factor

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1221 Flufenamic acid 99.93% Unkown
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139330 MGH-CP1 Inducer 99.56% Unkown
HY-158342 PROTAC TEAD degrader-1 Degrader 99.82% Unkown
HY-B1221S1 Flufenamic acid-13C6 / Unkown
HY-172113 H122 / Unkown
HY-161568 TEAD-IN-10 Inhibitor / Unkown
HY-161569 TEAD-IN-11 Inhibitor / Unkown
HY-173139 TEAD-IN-19 Inhibitor / Unkown
HY-B1221S Flufenamic acid-d4 / Unkown
HY-RS14343 TEAD2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19240 Tead2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25729 Tead2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tead2 NCBI NCBI:8463