2. Gene
  3. Adamts2 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 Gene

Adamts2 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as pNPI; PCINP; PC I-NP; ADAM-TS2; ADAMTS-2; ADAM-TS 2

Gene ID: 216725 | Gene type: protein coding

About Adamts2

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin repeats) family of proteinases that is involved in the proteolytic processing of procollagens. The encoded protein precursor is proteolytically processed to generate a mature, zinc-dependent enzyme. Mice lacking the encoded protein develop abnormal lungs, fragile skin and male sterility. [provided by RefSeq, Aug 2015]

Adamts2 Products(1)

mRNA Protein Name
NM_175643.3 NP_783574.1 A disintegrin and metalloproteinase with thrombospondin motifs 2 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables peptidase activity IDA
IDA: Inferred from direct assay
16556917 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
16556917 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
16556917 MGI
acts upstream of or within protein processing IMP
IMP: Inferred from mutant phenotype
16556917 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
11284712 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
11284712 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
16556917 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 2

a disintegrin and metalloproteinase with thrombospondin repeats

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2

procollagen I/II amino propeptide-processing enzyme

procollagen N-endopeptidase

procollagen N-

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00301 ADAMTS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19537 Adamts2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26033 Adamts2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adamts2 NCBI NCBI:9509