F8 - coagulation factor VIII Gene

Homo sapiens

Also known as AHF; F8B; F8C; HEMA; FVIII; THPH13; DXS1253E

Gene ID: 2157 | Gene type: protein coding

About F8

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,835,792-155,022,723 (from NCBI)

This gene has 7 transcripts (splice variants), 149 orthologues, 35 paralogues and is associated with 6 phenotypes. Broad expression in fat (RPKM 7.9), lung (RPKM 6.4) and 23 other tissues.

Summary

This gene encodes coagulation Factor VIII, which participates in the intrinsic pathway of blood coagulation; Factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and Phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]

F8 Products(4)

mRNA	Protein	Name
NM_000132.4	NP_000123.1	coagulation factor VIII isoform a preproprotein
NM_019863.3	NP_063916.1	coagulation factor VIII isoform b
NM_000132.4	NP_000123.1	coagulation factor VIII isoform a preproprotein
NM_019863.3	NP_063916.1	coagulation factor VIII isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7756647	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F8 Protein Structure

Cu-oxidase_3

Cu-oxidase

Cu-oxidase_3

Cu-oxidase_2

F5_F8_type_C

0
400
800
1200
1600
2000
2351 a.a.

Protein Preferred Names

Protein Names

coagulation factor VIII

antihemophilic factor

F8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	F8	P00451	VWF	Homo sapiens	P04275	ELISA	18492805
Intra	F8	P00451	VWF	Homo sapiens	P04275	SPR	27749002

Cross: Cross-species interaction Intra: Intraspecies interaction

F8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85156	Factor VIII Antibody (YA4848)	WB, ELISA	Human

Related Diseases

Diseases

Alias

Hemophilia A

Factor Viii Deficiency	Haemophilia A
Mild Hemophilia A	HEMA
Hemophilia, Classic	Classic Hemophilia
Factor 8 Deficiency	Severe Hemophilia A
Classical Hemophilia	Hem A
Hemophilia A, Congenital	Mild Congenital F8 Deficiency
Mild Congenital Factor Viii Deficiency	Severe Congenital F8 Deficiency
Severe Congenital Factor Viii Deficiency	Moderate Hemophilia A
Moderate Congenital F8 Deficiency	Moderate Congenital Factor Viii Deficiency
Bleeding Disorder In Hemophilia A Carriers	Congenital F8 Deficiency
Congenital Fviii Deficiency	Congenital Factor Viii Deficiency
Mild Hereditary Factor Viii Deficiency Disease	Severe Hereditary Factor Viii Deficiency Disease
Ahg - [Antihaemophilic Globulin] Deficiency	Ahg - [Antihaemophilic Globulin] Deficiency Disease
Congenital Factor Viii Disorder	Sex-Linked Factor Viii Deficiency
Antihaemophilic Globulin Deficiency	Classic Haemophilia
Familial Haemophilia	Haemophilia
Hereditary Haemophilia	Subhaemophilia
Haemophilia Nos

Thrombophilia, X-Linked, Due To Factor Viii Defect

Thrombophilia 13, X-Linked, Due To Factor Viii Defect

THPH13

Factor Viii Deficiency

Autosomal Hemophilia A	Hemophilia A
Autosomal Factor Viii Deficiency	Classic Hemophilia A
Congenital Factor Viii Disorder	Subhemophilia
Factor 8 Deficiency, Congenital	Factor Viii

Hemophilia B

Christmas Disease	Factor Ix Deficiency
F9 Deficiency	HEMB
Plasma Thromboplastin Component Deficiency	Congenital Factor Ix Deficiency
Mild Hemophilia B	Severe Hemophilia B
Congenital Factor Ix Disorder	Deficiency, Functional Factor Ix
Hem B	Mild Congenital F9 Deficiency
Mild Congenital Factor Ix Deficiency	Moderate Hemophilia B
Moderate Congenital F9 Deficiency	Moderate Congenital Factor Ix Deficiency
Severe Congenital F9 Deficiency	Severe Congenital Factor Ix Deficiency
Bleeding Disorder In Hemophilia B Carriers	Congenital F9 Deficiency
Recessive X-Linked Hemophilia B

Hemophilia

Haemophilia	Hemophilia, Familial
Hemophilia, Hereditary	Hemophilia A
Hemophilia, Nos

Hemarthrosis

Haemarthrosis Of Shoulder Joint	Haemarthrosis Of The Ankle And Foot
Haemarthrosis Of The Pelvic Region And Thigh	Hemarthrosis Involving Ankle And Foot
Hemarthrosis Involving Forearm	Hemarthrosis Involving Hand
Hemarthrosis Involving Lower Leg	Hemarthrosis Involving Pelvic Region And Thigh
Hemarthrosis Involving Shoulder Region	Hemarthrosis Involving Upper Arm
Hemarthrosis Of Ankle And/Or Foot	Hemarthrosis Of Forearm
Hemarthrosis Of Hand	Hemarthrosis Of Lower Leg
Hemarthrosis Of Shoulder	Hemarthrosis Of Shoulder Region
Hemarthrosis Of The Ankle And Foot	Hemarthrosis Of The Ankle And/Or Foot
Hemarthrosis Of The Forearm	Hemarthrosis Of The Hand
Hemarthrosis Of The Lower Leg	Hemarthrosis Of The Pelvic Region And Thigh
Hemarthrosis Of The Shoulder Region	Hemarthrosis Of The Upper Arm
Hemarthrosis Of Upper Arm

Von Willebrand'S Disease

Von Willebrand Disease	Von Willebrand Disorder
Vascular Pseudohemophilia	Hereditary Von Willebrand Disease
Vwd	Vascular Hemophilia
Von Willebrand'S-Jurgens' Disease	Von Willebrand-Jrgens Disease
Von Willebrand Factor Deficiency	Von Willebrand Factor, Deficiency
Angiohemophilia	Von Willebrand'S Factor Deficiency
Von Willebrand Diseases	Factor Viii Deficiency With Vascular Defect
Vascular Haemophilia	Willebrand Jurgen Thrombopathy
Pseudohaemophilia	Minot-Von Willebrand-Jurgen Disease
Angiohaemophilia	Angiohaemophilia A
Angiohaemophilia B

Cardiac Tamponade

Pericardial Tamponade

Rose'S Tamponade

Von Willebrand Disease, Type 1

Von Willebrand Disease Type 1	VWD1
Von Willebrand'S Disease 1	Von Willebrand Disease Type I
Von Willebrand Disease, Type I	Vwd, Type 1
Vwd Type 1	Von Willebrand Disease 1
Von Willebrand Factor Deficiency Type 1	Von Willebrand Disease, Type 1, Susceptibility To

Von Willebrand Disease, Type 3

Von Willebrand Disease Type 3	VWD3
Von Willebrand'S Disease 3	Von Willebrand Disease Type Iii
Von Willebrand Disease, Type Iii	Vwd, Type 3
Vwd Type 3	Von Willebrand Disease 3
Von Willebrand Disease Recessive Form	Von Willebrand Factor Deficiency Type 3

Von Willebrand Disease, Type 2

Von Willebrand Disease Type 2m	Von Willebrand Disease Type 2
Von Willebrand Disease Type 2a	Von Willebrand Disease Type 2b
Von Willebrand Disease Type 2n	VWD2
Von Willebrand'S Disease 2	Von Willebrand Disease Type Ii
Von Willebrand Disease, Type Ii	Vwd, Type 2
Von Willebrand Disease, Types 2a, 2b, 2m, And 2n	Vwd Type 2
Von Willebrand Disease 2	Von Willebrand Disease Normandy Variant
Von Willebrand Disease Type 2 Malmo	Von Willebrand Disease Type I New York
Von Willebrand Factor Deficiency Type 2	Vwd2a
Vwd2b	Vwd2m
Vwd2n	Von Willebrand Disease, Type 2a, 2b, 2m, And 2n
Von Willebrand Disease, Type 2a	Von Willebrand Disease, Type 2b
Von Willebrand Disease, Type 2n

Hemorrhagic Disease

Hemorrhagic Disorders	Hemorrhagic Diathesis
Hemorrhagic Diseases	Bleeding Tendency
Acquired Coagulation Factor Inhibitor Disorder	Acquired Inhibitor Of Coagulation
Antithrombinaemia	Antithromboplastinogenaemia
Circulating Anticoagulant Disorder	Haemorrhagic Disorder Due To Antithrombinaemia
Haemorrhagic Disorder Due To Excess Administered Heparin	Antithromboplastinaemia
Haemorrhagic Disorder Due To Hyperheparinemia

Thrombophilia

Hypercoagulability State

Blood Platelet Disease

Platelet Disorder	Blood Platelet Disorders
Thrombocytopathy	Platelet Dysfunction
Platelet Disorders	Qualitative Platelet Deficiency

Arthropathy

Ankylosis Of Ankle And Foot Joint	Ankylosis Of Forearm Joint
Ankylosis Of Hand Joint	Ankylosis Of Joint Of Ankle And/Or Foot
Ankylosis Of Joint Of Forearm	Ankylosis Of Joint Of Hand
Ankylosis Of Joint Of Lower Leg	Ankylosis Of Joint Of Multiple Sites
Ankylosis Of Joint Of Pelvic Region And Thigh	Ankylosis Of Joint Of Shoulder Region
Ankylosis Of Joint Of Upper Arm	Ankylosis Of Lower Leg Joint
Ankylosis Of Multiple Joints	Ankylosis Of Upper Arm Joint
Infectious Arthropathy	Joint Ankylosis Of The Ankle And Foot
Joint Ankylosis Of The Ankle And/Or Foot	Joint Ankylosis Of The Forearm
Joint Ankylosis Of The Hand	Joint Ankylosis Of The Lower Leg
Joint Ankylosis Of The Pelvic Region And Thigh	Joint Ankylosis Of The Shoulder Region
Joint Ankylosis Of The Upper Arm	Joint Diseases
Joint Disease	Arthropathy Associated With Infection

Factor V Deficiency

Parahemophilia	Labile Factor Deficiency
Proaccelerin Deficiency	Owren Disease
Owren Parahemophilia	Quebec Platelet Disorder
Deficiency, Labile	Hereditary Hypoproaccelerinaemia
Owren'S Disease	Congenital Factor V Deficiency
FA5D	Factor 5 Deficiency
Deficiency, Factor V

Factor Xiii Deficiency

Hereditary Factor Xiii Deficiency Disease	Deficiency, Laki-Lorand Factor
Congenital Factor Xiii Deficiency	Fibrin Stabilizing Factor Deficiency
Deficiency, Factor Xiii	Factor Xiii Deficiency Disease
Deficiency Of Factor Xiii	Fibrin-Stabilizing Factor Deficiency
Factor Xiii Deficiency, Congenital

Factor V And Factor Viii, Combined Deficiency Of, 2

Factor V And Factor Viii, Combined Deficiency Of	F5F8D2
Combined Deficiency Of Factor V And Factor Viii	F5f8d
Factor 5 And Factor Viii, Combined Deficiency Of, 2	Fv And Fviii Combined Deficiency
Factor V And Factor Viii Combined Deficiency 2	Mcfd2
Multiple Coagulation Factor Deficiency 2	Deficiency, Combined, Factor V And Factor Viii, Type 2

Thrombophilia Due To Activated Protein C Resistance

Activated Protein C Resistance	Apc Resistance
THPH2	Thrombophilia Due To Deficiency Of Activated Protein C Cofactor
Proc Cofactor Deficiency	Pccf Deficiency
Thrombophilia V	Thrombophilia, Susceptibility To, Due To Factor V Leiden
Thrombophilia Due To Factor V Leiden	Thrombophilia 2 Due To Activated Protein C Resistance
Thrombophilia, Susceptibility To, Due To Activated Protein C Resistance

Compartment Syndrome

Compartment Syndromes

Compartmental Syndrome

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Factor Vii Deficiency

Hypoproconvertinemia	F7 Deficiency
Congenital Proconvertin Deficiency	Congenital Factor Vii Deficiency
Factor 7 Deficiency	Deficiency, Stable
Proconvertin Deficiency	Prothrombin Conversion Accelerator Deficiency
Serum Prothrombin Conversion Accelerator Deficiency	Proconvertin Deficiency, Congenital
FA7D	Stable Disease
Deficiency, Factor Vii

Brachydactyly, Type D

Brachydactyly Type D	BDD
Stub Thumb	Brachydactyly D

Thrombosis

Thrombosis Of Blood Vessel

Acquired Von Willebrand Syndrome

Acquired Von Willebrand Disease	Willebrand Disease, Acquired
Avws

Vitamin K Deficiency Bleeding

Vitamin K Deficiency	Deficiency Of Vitamin K
Vitamin K	Vitamin K Deficiency Hemorrhagic Disease

Bernard-Soulier Syndrome

Giant Platelet Syndrome	BSS
Von Willebrand Factor Receptor Deficiency	Bdplt1
Platelet Glycoprotein Ib Deficiency	Bernard-Soulier Syndrome, Type A1
Bernard-Soulier Syndrome, Type B	Bernard Soulier Syndrome
Deficiency Of Platelet Glycoprotein 1b	Hemorrhagiparous Thrombocytic Dystrophy
Bernard-Soulier Syndrome Type C	Bleeding Disorder, Platelet-Type, 1
Glycoprotein Ib, Platelet, Deficiency Of	Giant Platelet Disorder, Isolated
Giant Platelet Disease	Macrothrombocytopenia, Familial Bernard-Soulier Type
Bernard-Soulier Syndrome, Type C	Bernard - Soulier Thrombopathy
Hemorrhagic Dystrophic Thrombocytopenia	Thrombopathy, Bernard-Soulier
Platelet Glycoprotein 1b, Deficiency Of	Hemorrhagioparous Thrombocytic Dystrophy
Bernard-Soulier Syndrome Type A1	Bernard-Soulier Syndrome Type B
Bleeding Disorder Platelet-Type 1	Gpd
Macrothrombocytopenia, Familial, Bernard-Soulier Type

Glanzmann Thrombasthenia 1

Glanzmann Thrombasthenia	Thrombasthenia Of Glanzmann And Naegeli
Glanzmann'S Thrombasthenia	Bdplt2
Platelet Glycoprotein Iib-Iiia Deficiency	Deficiency Of Platelet Fibrinogen Receptor
GT1	Gt
Platelet Fibrinogen Receptor Deficiency	Glycoprotein Complex Iib-Iiia Deficiency
Deficiency Of Glycoprotein Complex Iib-Iiia	Glycoprotein Iib/Iiia Defect
Glanzmann Thrombasthenia, Type A	Thrombasthenia
Bleeding Disorder, Platelet-Type, 2	Gp Iib-Iiia Complex Deficiency
Deficiency Of Gp Iib-Iiia Complex	Platelet-Type Bleeding Disorder 2
Thrombocytasthenia	Deficiency Of Gp 2b 3a Complex
Diacyclothrombopathia 2b 3a	Glanzmann Thrombasthenia Type A
Platelet Fibrinogen Receptor, Deficiency Of	Platelet Glycoprotein 2b 3a Deficiency
Glanzmann Disease	Glanzmann-Naegeli Disorder
Hereditary Hemorrhagic Thrombasthenia	Hereditary Thrombasthenia
Bleeding Disorder Platelet-Type 2

Thrombophilia Due To Thrombin Defect

Venous Thromboembolism	Venous Thrombosis
Thrombophilia Due To Factor 2 Defect	Thromboembolism
THPH1	Thromboembolism, Susceptibility To
Venous Thromboembolism, Susceptibility To	Venous Thrombosis, Protection Against
Prothrombin-Related Thrombophilia	Hyperprothrombinemia
Venous Thrombosis, Susceptibility To	Thrombophilia 1 Due To Thrombin Defect
F2-Related Thrombophilia	Factor Ii-Related Thrombophilia
Prothrombin 20210g>A Thrombophilia	Prothrombin G20210a Thrombophilia
Prothrombin Thrombophilia

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Afibrinogenemia, Congenital

Congenital Afibrinogenemia	Afibrinogenemia
Factor I Deficiency	Familial Afibrinogenemia
Hypofibrinogenemia, Congenital	Fibrinogen Deficiency
Afibrinogenemia Congenital	CAFBN
Congenital Hypofibrinogenemia	Hypofibrinogenemia
Complement Factor I Deficiency

Retinal Artery Occlusion

Retina Artery Narrowing	Retinal Artery Spasm
Spasm Of Ophthalmic Artery	Retinal Spasm
Vasospasm Of Retina

Intracranial Thrombosis

Cerebral Thrombosis	Thrombosis Of Cerebral Veins
Cerebral Arterial Thrombosis

Hepatic Veno-Occlusive Disease

Veno-Occlusive Disease	Sinusoidal Obstruction Syndrome
Hepatic Venoocclusive Disease	Venoocclusive Disease
Hepatic Vein Thrombosis	Budd-Chiari Syndrome
Hepatic Vein Occlusion	Veno-Occlusive Disease Of The Liver

Childhood Angiosarcoma

Paediatric Angiosarcoma	Paediatric Hemangiosarcoma
Pediatric Angiosarcoma	Pediatric Hemangiosarcoma

Thrombophlebitis

Phlebitis And Thrombophlebitis Of Superficial Vessels Of Lower Extremities	Superficial Thrombophlebitis Of Leg
Thrombophlebitis Of A Superficial Leg Vein	Thrombophlebitis Of Superficial Veins Of Lower Extremity

Prothrombin Deficiency

Factor Ii Deficiency	Hypoprothrombinemia
Dysprothrombinemia	Deficiency, Prothrombin
Inherited Factor Ii Deficiency	Hereditary Factor Ii Deficiency Disease

Blood Coagulation Disease

Blood Coagulation Disorders	Coagulation Protein Disease
Inherited Blood Coagulation Disease	Postpartum Coagulation Defect
Postpartum Coagulation Defect With Delivery	Coagulation Protein Disorders
Puerperal Coagulopathy

Pulmonary Embolism

Pulmonary Artery Embolism	Pulmonary Embolus
Pulmonary Emboli

Portal Vein Thrombosis

Phlebitis Of Portal Vein	Deep Vein Thrombosis Of Portal Vein
Portal Thrombosis	Pvt - [Portal Vein Thrombosis]
Portal Venous Thrombosis	Portal Venous Embolism
Portal Venous Obstruction	Portal Venous Block
Portal Vein Embolism	Portal Vein Block
Portal Obstruction	Portal Embolism
Portal Block	Hepatic Portal Vein Obstruction
Occlusion Of Hepatic Portal Vein	Portal Vein Obstruction

Factor Xi Deficiency

Plasma Thromboplastin Antecedent Deficiency	Rosenthal Syndrome
Pta Deficiency	Hemophilia C
Rosenthal Factor Deficiency	F11 Deficiency
Congenital Factor Xi Deficiency	Hereditary Factor Xi Deficiency Disease
Haemophilia C	Factor Xi Deficiency, Autosomal Dominant
Rosenthal'S Disease	Factor 11 Deficiency
Factor Xi	Factor Xi Deficiency, Autosomal Recessive
Factor Xi Deficiency, Congenital	FA11D
Thromboplastin Antecedent Deficiency	Pta - [Plasma Thromboplastin Antecedent] Deficiency
Congenital Factor Xi Deficiency Disease	Rosenthal Disease

Sneddon Syndrome

Livedo Reticularis And Cerebrovascular Accidents	SNDNS
Ehrmann-Sneddon Syndrome	Livedo Racemosa-Cerebrovascular Accident Syndrome
Livedo Reticularis-Cerebrovascular Accident Syndrome	Sneddon'S Syndrome
Idiopathic Livedo Reticularis With Systemic Involvement	Cerebro-Vascular Lesions And Livedo Reticularis
Livedo Racemosa And Cerebrovascular Accidents

Thrombotic Thrombocytopenic Purpura

Purpura, Thrombotic Thrombocytopenic	Ttp
Thrombotic Thrombocytopenic Purpura, Acquired	Idiopathic Thrombotic Thrombocytopenic Purpura
Moschcowitz Disease	Moschcowitz'S Syndrome
Moschowitz Syndrome	Chronic Relapsing Thrombotic Thrombocytopenic Purpura
Familial Thrombotic Thrombocytopenia Purpura	Moschkowitz Disease
Purpura Thrombotic Thrombocytopenic	Familial Thrombotic Thrombocytopenic Purpura
Microangiopathic Hemolytic Anemia	Congenital Thrombotic Thrombocytopenic Purpura
Autoimmune Thrombotic Thrombocytopenic Purpura	Ttp - [Thrombotic Thrombocytopenic Purpura]
Moschcowitz Syndrome

Thrombocytopenic Purpura, Autoimmune

Idiopathic Thrombocytopenic Purpura	Autoimmune Thrombocytopenic Purpura
Immune Thrombocytopenic Purpura	Itp
Idiopathic Purpura	AITP
Ideopath Thrombocytopenic Pur	Primary Thrombocytopenic Purpura
Werlhof'S Disease	Thrombocytopenic Purpura Autoimmune
Purpura Thrombocytopenic Idiopathic	Purpura, Thrombocytopenic, Idiopathic
Autoimmune Thrombocytopenia	Thrombocytopenia Due To Platelet Alloimmunization
Idiopathic Thrombocytopenia	Idiopathic Thrombocytopenia Purpura
Frank'S Essential Thrombocytopenia	Itp - [Idiopathic Thrombocytopenia Purpura]
Werlhof Disease	Primary Autoimmune Thrombocytopenic Purpura
Haemorrhagic Purpura	Essential Thrombocytopenia
Purpura Haemorrhagica

Homocystinuria

Cystathionine Beta Synthase Deficiency	Homocysteinemia
Cbs Deficiency	Cystathionine Synthase Deficiency
Cystathionine Beta-Synthase Deficiency Disease

Breast Hemangioma

Angioma Of The Breast	Hemangioma Of Breast
Haemangioma Of Breast

Hobnail Hemangioma

Pseudo-Von Willebrand Disease

Bdplt3	Von Willebrand Disease, Platelet-Type
VWDP	Platelet-Type Bleeding Disorder 3
Platelet Type-Von Willebrand Disease	Pt-Vwd
Von Willebrand Disease Platelet-Type	Von Willebrand Disease, Platelet Type
Pseudo Von Willebrand Disease	Bleeding Disorder, Platelet-Type, 3
Pseudo-Von Willebrand Disease Type 2b	Bleeding Disorder Platelet-Type 3
Pseudo-Vwd

Angiodysplasia

Angiodysplasia Of Colon	Angiodysplasia Of Stomach And Duodenum With Hemorrhage
Angiodysplasia Of Large Intestine	Telangiectasia Of Colon
Vascular Ectasia Of Colon	Av - [Angiodysplasia Malformation Of Colon]
Colon Angiodysplasia	Colonic Angiodysplasia
Vascular Ectasia Of Large Intestine

Synovial Angioma

Hemangioma Of Synovium

Synovial Hemangioma

Hypothyroidism

Thyroid Diseases	Thyroid Disease
Thyroid Deficiency	Thyroid Insufficiency
Dysfunction Thyroid	Thyroid Dysfunction

Post-Thrombotic Syndrome

Postphlebitic Syndrome	Postthrombotic Syndrome
Postphlebetic Syndrome With Inflammation	Postphlebetic Syndrome With Ulcer
Postphlebetic Syndrome With Ulcer And Inflammation	Venous Stress Disorder

Cerebral Arteritis

Brain Endarteritis	Cerebral Or Cerebrospinal Endarteritis
Brain Arteritis

Intracranial Sinus Thrombosis

Sinus Thrombosis, Intracranial

Alpha-2-Plasmin Inhibitor Deficiency

Plasmin Inhibitor Deficiency	Antiplasmin Deficiency
Antiplasmin Defiency	Anti-Plasmin Deficiency, Congenital
Antiplasmin Deficiency, Congenital	Congenital Alpha2-Antiplasmin Deficiency
APLID	Congenital Alpha2 Antiplasmin Deficiency

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Factor X Deficiency

Stuart-Prower Factor Deficiency	F10 Deficiency
Congenital Stuart Factor Deficiency	Factor X Deficiency, Congenital
Congenital Factor X Deficiency	Disease, Stuart-Prower
Stuart Factor Deficiency, Congenital	FA10D
Factor 10 Deficiency	Deficiency, Factor X
Hereditary Factor X Deficiency Disease	Deficiency Of Factor X
Stuart Deficiency Disease	Stuart Prower Deficiency
Stuart-Prower Disease

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Pulmonary Artery Disease

Abnormality Of The Pulmonary Artery

Vein Disease

Disorder Of Vein

Diabetes Mellitus

Diabetes

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Brachydactyly

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9964	Necitumumab	Inhibitor	99.51%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-107530	3F8	Inhibitor	/	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99757	Nivatrotamab	Inhibitor	99.40%	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D2377	F8		98.25%	Unkown
HY-157252	CL4F8-6		99.80%	Unkown
HY-171036	GAPDH-IN-1	Inhibitor	98.1%	Unkown
HY-147844	F8-S43-S3	Inhibitor	/	Unkown
HY-147845	F8-S40	Inhibitor	/	Unkown
HY-157125	PI3Kα-IN-14		/	Unkown
HY-RS04117	E2F8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04646	F8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04647	F8A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17355	F8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22149	E2f8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23809	F8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W391641	F8BT		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990221	Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)	Inhibitor	≥95.0%	Unkown
HY-P990214	Anti-Mouse IL-3 Antibody (MP2-8F8)	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	F8	MGD	MGI:88383
Rattus norvegicus	F8	RGD	RGD:727845
Canis familiaris	F8	VGNC	VGNC:40553
Bos taurus	F8	VGNC	VGNC:28690
Macaca mulatta	F8	VGNC	VGNC:72467
Felis catus	F8	NCBI	NCBI:101092751
Macaca fascicularis	F8	NCBI	NCBI:102125498
Others	F8	NCBI