Tcf3 - transcription factor 3 Gene

Mus musculus

Also known as A1; E12; E2A; E47; KA1; ME2; ALF2; Pan1; Pan2; VDIR; TCF-3; Tcfe2a; E12/E47; bHLHb21

Gene ID: 21423 | Gene type: protein coding

About Tcf3

Summary

Enables several functions, including E-box binding activity; protein heterodimerization activity; and transmembrane receptor protein tyrosine kinase activator activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in gastrulation; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including histone acetylation; immune system development; and regulation of gene expression. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex and nucleosome. Is expressed in several structures, including branchial arch; central nervous system; male reproductive system; retina; and urinary system. Human ortholog(s) of this gene implicated in agammaglobulinemia and colorectal Cancer. Orthologous to human TCF3 (transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Tcf3 Products(16)

mRNA	Protein	Name
NM_001164147.2	NP_001157619.1	transcription factor E2-alpha isoform 1
NM_001164148.2	NP_001157620.1	transcription factor E2-alpha isoform 2
NM_001164149.2	NP_001157621.1	transcription factor E2-alpha isoform 3
NM_001164150.2	NP_001157622.1	transcription factor E2-alpha isoform 4
NM_001164151.2	NP_001157623.1	transcription factor E2-alpha isoform 5
NM_001164152.2	NP_001157624.1	transcription factor E2-alpha isoform 6
NM_001164153.2	NP_001157625.1	transcription factor E2-alpha isoform 7
NM_001378903.1	NP_001365832.1	transcription factor E2-alpha isoform 9
NM_001378904.1	NP_001365833.1	transcription factor E2-alpha isoform 10
NM_001378905.1	NP_001365834.1	transcription factor E2-alpha isoform 11
NM_001378908.1	NP_001365837.1	transcription factor E2-alpha isoform 12
NM_001378910.1	NP_001365839.1	transcription factor E2-alpha isoform 13
NM_001378912.1	NP_001365841.1	transcription factor E2-alpha isoform 14
NM_001378913.1	NP_001365842.1	transcription factor E2-alpha isoform 15
NM_001378914.1	NP_001365843.1	transcription factor E2-alpha isoform 16
NM_011548.5	NP_035678.3	transcription factor E2-alpha isoform 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18361414	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11812799	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	12446773	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16673016	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12200424	MGI
contributes to E-box binding	IDA IDA: Inferred from direct assay	11812799	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	15226298	MGI
enables E-box binding	IPI IPI: Inferred from physical interaction	9545521	MGI
contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18361414	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12446773	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	12446773	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11812799	MGI
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	9545521	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	18550854	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16140986	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	14757642	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10924525	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	18214987	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16428437	MGI
enables sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	12070084	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Peyer's patch development	IGI IGI: Inferred from genetic interaction	17452521	MGI
acts upstream of or within T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	18958875	MGI
acts upstream of or within cell development	IGI IGI: Inferred from genetic interaction	17452521	MGI
acts upstream of or within chromatin remodeling	IMP IMP: Inferred from mutant phenotype	16428437	MGI
involved in gastrulation	IGI IGI: Inferred from genetic interaction	21828274	MGI
acts upstream of gene expression	IMP IMP: Inferred from mutant phenotype	18958875	MGI
acts upstream of or within immunoglobulin V(D)J recombination	IMP IMP: Inferred from mutant phenotype	16428437	MGI
acts upstream of or within lymphocyte differentiation	IMP IMP: Inferred from mutant phenotype	18958875	MGI
acts upstream of or within natural killer cell differentiation	IGI IGI: Inferred from genetic interaction	17452521	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	12070084	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18958875	MGI
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	18214987	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8760303	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11812799	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	8900141	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12446773	MGI
acts upstream of or within protein stabilization	IDA IDA: Inferred from direct assay	15322112	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15351717	MGI
acts upstream of or within regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	9676199	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19796622	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	16428437	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	16428437	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16428437	MGI
acts upstream of positive effect transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16673016	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	18361414	MGI
part of RNA polymerase II transcription regulator complex	IMP IMP: Inferred from mutant phenotype	30426815	MGI
located in cytosol	IDA IDA: Inferred from direct assay	17507657	MGI
part of nucleosome	IDA IDA: Inferred from direct assay	16428437	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12200424	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	8760303	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	15314159	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor E2-alpha

immunoglobulin enhancer-binding factor E12/E47	transcription factor A1
transcription factor E2a

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14306	TCF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14309	TCF7L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18501	Tcf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24983	Tcf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tcf3	NCBI	NCBI:6929

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