Zeb1 - zinc finger E-box binding homeobox 1 Gene

Mus musculus

Also known as Tw; BZP; ZEB; MEB1; Nil2; Tcf8; AREB6; TCF-8; Tcf18; Zfhep; Zfx1a; Zfhx1a; Zfx1ha; [delta]EF1; 3110032K11Rik

Gene ID: 21417 | Gene type: protein coding

About Zeb1

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of neuron differentiation. Acts upstream of or within several processes, including embryonic organ morphogenesis; regulation of T cell differentiation in thymus; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; embryo mesoderm; and genitourinary system. Used to study tropical spastic paraparesis. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Zeb1 Products(3)

mRNA	Protein	Name
NM_001360981.1	NP_001347910.1	zinc finger E-box-binding homeobox 1 isoform 2
NM_001360982.1	NP_001347911.1	zinc finger E-box-binding homeobox 1 isoform 3
NM_011546.3	NP_035676.1	zinc finger E-box-binding homeobox 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	24735878	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	20346398	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16824956	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16824956	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within animal organ development	IMP IMP: Inferred from mutant phenotype	11681996	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	9389660	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18436818	MGI
acts upstream of or within cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	20548288	MGI
acts upstream of or within central nervous system development	IGI IGI: Inferred from genetic interaction	16598713	MGI
acts upstream of or within cochlea morphogenesis	IMP IMP: Inferred from mutant phenotype	21980308	MGI
acts upstream of or within embryonic camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	18436818	MGI
acts upstream of or within embryonic morphogenesis	IGI IGI: Inferred from genetic interaction	16598713	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	9389660	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18436818	MGI
acts upstream of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	18436818	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20346398	MGI
acts upstream of or within negative regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	18192284	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18436818	MGI
acts upstream of or within negative regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	18436818	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20713358	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17392792	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	9389660	MGI
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	20346398	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16824956	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16824956	MGI
acts upstream of or within regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	9126927	MGI
acts upstream of or within regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	18192284	MGI
acts upstream of or within regulation of smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	16824956	MGI
acts upstream of or within regulation of transforming growth factor beta receptor signaling pathway	IGI IGI: Inferred from genetic interaction	16824956	MGI
acts upstream of or within semicircular canal morphogenesis	IMP IMP: Inferred from mutant phenotype	21980308	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	14643678	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zinc finger E-box-binding homeobox 1

transcription factor 8	twirler
zinc finger homeobox protein 1a

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0153	Naringin		99.65%	Unkown
HY-W011338	Benzyl butyl phthalate	Activator	≥97.0%	Unkown
HY-131445	RJW100	Activator	99.93%	Unkown
HY-W011338S	Benzyl butyl phthalate-d4		98.38%	Unkown
HY-RS16025	ZEB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N0153R	Naringin (Standard)		/	Unkown
HY-RS16881	Zeb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23323	Zeb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zeb1	NCBI	NCBI:6935

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