Hnf1a - HNF1 homeobox A Gene

Mus musculus

Also known as HNF1; LFB1; Tcf1; Hnf-1; Tcf-1; HNF1[a]; Hnf1alpha; HNF1-alpha

Gene ID: 21405 | Gene type: protein coding

About Hnf1a

Summary

This gene encodes a hepatic transcription factor. The encoded protein is not a member of the T-cell factor family, and is distinct from T-cell specific transcription factor 7 which has also been referred to by the symbol Tcf1. [provided by RefSeq, Jul 2008]

Hnf1a Products(1)

mRNA	Protein	Name
NM_009327.3	NP_033353.2	hepatocyte nuclear factor 1-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	1363228	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	2044952	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	8598044	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11287626	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	22780989	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	1685988	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	2044952	MGI
enables protein dimerization activity	IPI IPI: Inferred from physical interaction	11106484	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in D-glucose import	IDA IDA: Inferred from direct assay	11269503	MGI
acts upstream of or within bile acid and bile salt transport	IMP IMP: Inferred from mutant phenotype	11279518	MGI
acts upstream of or within bile acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	11279518	MGI
acts upstream of or within cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	11279518	MGI
acts upstream of or within chromatin remodeling	IMP IMP: Inferred from mutant phenotype	11733582	MGI
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	12367519	MGI
acts upstream of or within fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	10852923	MGI
acts upstream of or within fatty acid transport	IMP IMP: Inferred from mutant phenotype	10852923	MGI
involved in glucose homeostasis	IDA IDA: Inferred from direct assay	11269503	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	9593777	MGI
acts upstream of or within heme biosynthetic process	IMP IMP: Inferred from mutant phenotype	10617683	MGI
acts upstream of or within insulin secretion	IMP IMP: Inferred from mutant phenotype	9566924	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	9566924	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	2044952	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11269503	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	8598044	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12367519	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15581617	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11287626	MGI
acts upstream of or within regulation of hormone secretion	IMP IMP: Inferred from mutant phenotype	9566924	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9689059	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	22589549	MGI
involved in renal D-glucose absorption	IDA IDA: Inferred from direct assay	11269503	MGI
acts upstream of or within reproductive structure development	IMP IMP: Inferred from mutant phenotype	9566924	MGI
acts upstream of or within response to glucose	IMP IMP: Inferred from mutant phenotype	9733737	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	10617683	MGI
acts upstream of or within reverse cholesterol transport	IMP IMP: Inferred from mutant phenotype	15793583	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	1363228	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	14570708	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hepatocyte nuclear factor 1-alpha

liver-specific transcription factor LF-B1

transcription factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06255	HNF1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19690	Hnf1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26185	Hnf1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hnf1a	NCBI	NCBI:6927

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