2. Gene
  3. Dhtkd1 - dehydrogenase E1 and transketolase domain containing 1 Gene

Dhtkd1 - dehydrogenase E1 and transketolase domain containing 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as E1a; OADC-E1; OADH-E1; C330018I04Rik

Gene ID: 209692 | Gene type: protein coding

About Dhtkd1

Summary

Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity and thiamine pyrophosphate binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in mitochondrion. Used to study Charcot-Marie-Tooth disease axonal type 2Q and amino acid metabolic disorder. Human ortholog(s) of this gene implicated in 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth disease axonal type 2Q. Orthologous to human DHTKD1 (dehydrogenase E1 and Transketolase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Dhtkd1 Products(1)

mRNA Protein Name
NM_001081131.2 NP_001074600.1 2-oxoadipate dehydrogenase complex component E1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within hematopoietic progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
24029230 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

2-oxoadipate dehydrogenase complex component E1

probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

2-oxoadipate dehydrogenase, mitochondrial

alpha-KADH-E1

alpha-ketoadipate dehydrogenase

dehydrogenase E1 and transketolase domain-containing protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03747 DHTKD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21844 Dhtkd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dhtkd1 NCBI NCBI:55526