Tfe3 - transcription factor E3 Gene

Mus musculus

Also known as Tcfe3; Tfe-3; mTFE3; bHLHe33; F830016E06Rik

Gene ID: 209446 | Gene type: protein coding

About Tfe3

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; positive regulation of brown fat cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription, DNA-templated and regulation of osteoclast differentiation. Located in cytosol and nucleus. Is expressed in several structures, including adipose tissue; branchial arch; early conceptus; genitourinary system; and gut. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human TFE3 (transcription factor binding to IGHM enhancer 3). [provided by Alliance of Genome Resources, Apr 2022]

Tfe3 Products(6)

mRNA	Protein	Name
NM_001105196.1	NP_001098666.1	transcription factor E3 isoform b
NM_001105197.1	NP_001098667.1	transcription factor E3 isoform c
NM_001271489.1	NP_001258418.1	transcription factor E3 isoform c
NM_001271490.1	NP_001258419.1	transcription factor E3 isoform c
NM_001271491.1	NP_001258420.1	transcription factor E3 isoform d
NM_172472.3	NP_766060.2	transcription factor E3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15994295	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16936731	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	20713358	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20713358	MGI
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	16936731	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	16936731	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in humoral immune response	IMP IMP: Inferred from mutant phenotype	16936731	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	23885019	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15994295	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	27913603	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	29146937	MGI
involved in positive regulation of brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	27913603	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16936731	MGI
acts upstream of or within regulation of osteoclast differentiation	IGI IGI: Inferred from genetic interaction	11930005	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	21209915	MGI
located in cytosol	IDA IDA: Inferred from direct assay	27913603	MGI
located in nucleus	IDA IDA: Inferred from direct assay	21209915	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor E3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14419	TFE3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19388	Tfe3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25880	Tfe3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tfe3	NCBI	NCBI:7030

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