Stat5a - signal transducer and activator of transcription 5A Gene

Mus musculus

Also known as STAT5

Gene ID: 20850 | Gene type: protein coding

About Stat5a

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and phosphate ion binding activity. Involved in growth hormone receptor signaling pathway via JAK-STAT and regulation of growth. Acts upstream of or within several processes, including animal organ development; positive regulation of leukocyte proliferation; and regulation of hemopoiesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and liver and biliary system. Orthologous to human STAT5A (signal transducer and activator of transcription 5A). [provided by Alliance of Genome Resources, Apr 2022]

Stat5a Products(3)

mRNA	Protein	Name
NM_001164062.1	NP_001157534.1	signal transducer and activator of transcription 5A isoform 2
NM_001362680.1	NP_001349609.1	signal transducer and activator of transcription 5A isoform 1
NM_011488.3	NP_035618.1	signal transducer and activator of transcription 5A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10485657	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12393611	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	12393611	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19666510	MGI
enables phosphate ion binding	IDA IDA: Inferred from direct assay	8702683	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8702683	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12393611	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell differentiation	IGI IGI: Inferred from genetic interaction	10979977	MGI
acts upstream of or within Peyer's patch development	IGI IGI: Inferred from genetic interaction	15294943	MGI
acts upstream of or within T cell differentiation in thymus	IGI IGI: Inferred from genetic interaction	15294943	MGI
acts upstream of or within T cell homeostasis	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	15947484	MGI
acts upstream of activated T cell proliferation	IDA IDA: Inferred from direct assay	10072077	MGI
acts upstream of activated T cell proliferation	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of cell population proliferation	IDA IDA: Inferred from direct assay	10652277	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	10652277	MGI
acts upstream of or within cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	10485657	MGI
acts upstream of or within cellular response to granulocyte macrophage colony-stimulating factor stimulus	IDA IDA: Inferred from direct assay	23610142	MGI
acts upstream of or within cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	10485657	MGI
acts upstream of or within development of secondary female sexual characteristics	IMP IMP: Inferred from mutant phenotype	9630227	MGI
acts upstream of or within development of secondary male sexual characteristics	IGI IGI: Inferred from genetic interaction	9630227	MGI
acts upstream of or within development of secondary male sexual characteristics	IMP IMP: Inferred from mutant phenotype	9630227	MGI
acts upstream of or within epithelial cell differentiation involved in prostate gland development	IMP IMP: Inferred from mutant phenotype	10908145	MGI
acts upstream of erythrocyte differentiation	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of or within female pregnancy	IGI IGI: Inferred from genetic interaction	15471942	MGI
acts upstream of gamma-delta T cell differentiation	IGI IGI: Inferred from genetic interaction	15294943	MGI
involved in growth hormone receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	8702683	MGI
acts upstream of interleukin-2 production	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of or within lactation	IMP IMP: Inferred from mutant phenotype	9630227	MGI
acts upstream of or within lipid storage	IGI IGI: Inferred from genetic interaction	9630227	MGI
acts upstream of or within luteinization	IGI IGI: Inferred from genetic interaction	9630227	MGI
acts upstream of lymphocyte differentiation	IGI IGI: Inferred from genetic interaction	15294943	MGI
acts upstream of or within mammary gland development	IMP IMP: Inferred from mutant phenotype	9630227	MGI
acts upstream of or within mammary gland epithelium development	IGI IGI: Inferred from genetic interaction	12040017	MGI
acts upstream of or within mammary gland epithelium development	IMP IMP: Inferred from mutant phenotype	12040017	MGI
acts upstream of mast cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15947484	MGI
acts upstream of mast cell differentiation	IMP IMP: Inferred from mutant phenotype	15947484	MGI
acts upstream of mast cell proliferation	IMP IMP: Inferred from mutant phenotype	15947484	MGI
acts upstream of mitotic cell cycle	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of myeloid cell apoptotic process	IGI IGI: Inferred from genetic interaction	10652277	MGI
acts upstream of or within natural killer cell differentiation	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of or within negative regulation of erythrocyte differentiation	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of or within negative regulation of mast cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15947484	MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process	IGI IGI: Inferred from genetic interaction	10652277	MGI
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	12388746	MGI
acts upstream of or within positive regulation of B cell differentiation	IGI IGI: Inferred from genetic interaction	10979977	MGI
acts upstream of or within positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	15947484	MGI
acts upstream of or within positive regulation of activated T cell proliferation	IDA IDA: Inferred from direct assay	10072077	MGI
acts upstream of or within positive regulation of activated T cell proliferation	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10652277	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	10652277	MGI
acts upstream of or within positive regulation of gamma-delta T cell differentiation	IGI IGI: Inferred from genetic interaction	15294943	MGI
acts upstream of or within positive regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	10652277	MGI
acts upstream of or within positive regulation of interleukin-2 production	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of or within positive regulation of lymphocyte differentiation	IGI IGI: Inferred from genetic interaction	15294943	MGI
acts upstream of or within positive regulation of mast cell differentiation	IMP IMP: Inferred from mutant phenotype	15947484	MGI
acts upstream of or within positive regulation of mast cell proliferation	IMP IMP: Inferred from mutant phenotype	15947484	MGI
acts upstream of or within positive regulation of mitotic cell cycle	IGI IGI: Inferred from genetic interaction	10072077	MGI
acts upstream of or within positive regulation of multicellular organism growth	IGI IGI: Inferred from genetic interaction	9630227	MGI
acts upstream of or within positive regulation of natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	9841920	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19666510	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	10485657	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9630227	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12393611	MGI
acts upstream of or within prostate gland epithelium morphogenesis	IMP IMP: Inferred from mutant phenotype	10908145	MGI
acts upstream of or within regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	11706048	MGI
acts upstream of or within regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	11706048	MGI
involved in regulation of multicellular organism growth	IGI IGI: Inferred from genetic interaction	18648510	MGI
acts upstream of or within regulation of steroid metabolic process	IGI IGI: Inferred from genetic interaction	15471942	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21217760	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15294943	MGI
acts upstream of or within response to peptide hormone	IDA IDA: Inferred from direct assay	12388746	MGI
acts upstream of positive effect taurine metabolic process	IGI IGI: Inferred from genetic interaction	18648510	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	10485657	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9630227	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11254359	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12456807	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

signal transducer and activator of transcription 5A

mammary gland factor STAT5A

Stat5a Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80904A	STAT5 Antibody (PBS only)	WB, ICC/IF, IP	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148813	AK-2292		99.73%	Unkown
HY-136546	Stafia-1	Inhibitor	99.37%	Unkown
HY-19527	IST5-002		99.83%	Unkown
HY-112648	Stafib-2	Inhibitor	98.42%	Unkown
HY-115464	NC1153		/	Unkown
HY-170837	STAT5-IN-3	Inhibitor	/	Unkown
HY-RS13892	STAT5A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19077	Stat5a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25568	Stat5a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stat5a	NCBI	NCBI:6776

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