2. Gene
  3. Spr - sepiapterin reductase Gene

Spr - sepiapterin reductase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gm10328

Gene ID: 20751 | Gene type: protein coding

About Spr

Summary

Enables protein homodimerization activity. Acts upstream of or within several processes, including Catecholamine metabolic process; serotonin metabolic process; and voluntary musculoskeletal movement. Located in mitochondrion. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and skeleton. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase). [provided by Alliance of Genome Resources, Apr 2022]

Spr Products(1)

mRNA Protein Name
NM_011467.2 NP_035597.2 sepiapterin reductase
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
9405351 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within L-phenylalanine metabolic process IMP
IMP: Inferred from mutant phenotype
16532389 MGI
acts upstream of or within cell morphogenesis involved in neuron differentiation IMP
IMP: Inferred from mutant phenotype
16532389 MGI
acts upstream of or within dopamine metabolic process IMP
IMP: Inferred from mutant phenotype
16532389 MGI
acts upstream of or within norepinephrine metabolic process IMP
IMP: Inferred from mutant phenotype
16532389 MGI
acts upstream of or within pteridine metabolic process IMP
IMP: Inferred from mutant phenotype
16532389 MGI
acts upstream of or within regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
16532389 MGI
acts upstream of or within serotonin metabolic process IMP
IMP: Inferred from mutant phenotype
16532389 MGI
acts upstream of or within tetrahydrobiopterin metabolic process IMP
IMP: Inferred from mutant phenotype
16532389 MGI
acts upstream of or within voluntary musculoskeletal movement IMP
IMP: Inferred from mutant phenotype
16532389 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sepiapterin reductase

Related Agents

Approval
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9905 Cetuximab Inhibitor 99.70% Unkown
Clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Phase
HY-101533 AZD-5991 Inhibitor 99.79% Phase 2
HY-135655 Fobrepodacin disodium Inhibitor 99.53% Phase 2
HY-113603 Tildacerfont Inhibitor 98.25% Phase 2
HY-135655A Fobrepodacin Inhibitor / Phase 2
HY-128780B SPR206 acetate Inhibitor 98.88% Phase 1
HY-P1649B SPR741 acetate Inhibitor 99.44% Phase 1
HY-P1649 SPR741 Inhibitor 99.08% Phase 1
HY-101533B AZD-5991 (S-enantiomer) Inhibitor 99.83% Phase 1
HY-128780 Upleganan Inhibitor / Phase 1
HY-P1649A SPR741 TFA Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (39)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13963 ZCL278 Inhibitor 98.49% Unkown
HY-115510 SPR inhibitor 3 Inhibitor 99.01% Unkown
HY-122611A CSRM617 hydrochloride 99.97% Unkown
HY-114388 QM385 Inducer 99.48% Unkown
HY-135691 hnRNPK-IN-1 97.0% Unkown
HY-160477 DC-SX029 Inhibitor 98.07% Unkown
HY-12930 SPR719 Inhibitor 99.39% Unkown
HY-101964 SPI-112 Inhibitor 98.01% Unkown
HY-P3143 BMSpep-57 Inhibitor 99.84% Unkown
HY-Y1049 2-Amino-6-bromopyridine Inhibitor 99.97% Unkown
HY-159652 KRAS inhibitor-31 Inhibitor 99.36% Unkown
HY-162960 pan-KRAS degrader 1 Degrader 99.93% Unkown
HY-101931 hVEGF-IN-1 Inhibitor 99.26% Unkown
HY-113603S Tildacerfont-d8 / Unkown
HY-175207 CHI3L1-IN-3 Inhibitor 98.95% Unkown
HY-P3143A BMSpep-57 hydrochloride Inhibitor 99.69% Unkown
HY-116992 Chloroneb Inhibitor ≥95.0% Unkown
HY-122611 CSRM617 / Unkown
HY-13963S ZCL278-13C / Unkown
HY-150506 SPR7 Inhibitor / Unkown
HY-152220 SPR39 Inhibitor / Unkown
HY-152222 SPR38 Inhibitor / Unkown
HY-152224 SPR41 Inhibitor / Unkown
HY-160481 MG-1102 Inhibitor / Unkown
HY-161841 Antitumor agent-177 Inhibitor / Unkown
HY-168536 SJ46411 / Unkown
HY-168847 INCB159020 Inhibitor / Unkown
HY-169311 KRAS inhibitor-37 Inhibitor / Unkown
HY-172196 LH168 / Unkown
HY-176537 RGN6024 / Unkown
HY-176732 MJ-26 Inhibitor / Unkown
HY-177512 MSC778 Inhibitor / Unkown
HY-P3852 Neurokinin Receptor (393-407), rat / Unkown
HY-RS13708 SPR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14143 TACR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14144 Tacr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-168535 SJ6145 / Unkown
HY-RS16730 Spr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23166 Spr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9S0008 Cetuximab (PBS) Inhibitor 99.23% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spr NCBI NCBI:6697