2-Amino-6-bromopyridine

Cat. No.: HY-Y1049 Purity: 99.77%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

2-Amino-6-bromopyridine is an intermediate. 2-Amino-6-bromopyridine is also a PqsR ligand with a K_d value of 6.8 μM in SPR assay. 2-Amino-6-bromopyridine shows weak antagonistic activity. 2-Amino-6-bromopyridine can be used in the synthesis of JAK2 inhibitors, MSK1 inhibitors, and in the research of Pseudomonas aeruginosa infection.

For research use only. We do not sell to patients.

2-Amino-6-bromopyridine Chemical Structure

CAS No. : 19798-81-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
> 100 g	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

2-Amino-6-bromopyridine (Compound 7) exhibits binding affinity to PqsR, with a K_d of 6.8 µM (in SPR)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

173.01

Formula

C₅H₅BrN₂

CAS No.

19798-81-3

Appearance

Solid

Color

Off-white to light brown

SMILES

NC1=NC(Br)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 200 mg/mL (1155.98 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.7799 mL	28.8996 mL	57.7991 mL
5 mM	1.1560 mL	5.7799 mL	11.5598 mL
10 mM	0.5780 mL	2.8900 mL	5.7799 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (245 KB)

Handling Instructions (2659 KB)

References

[1]. Michael Zender, et al. Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence. J Med Chem. 2013 Sep 12;56(17):6761-74. [Content Brief]

[2]. Siu M, et al. 2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors. Bioorg Med Chem Lett. 2013 Sep 1;23(17):5014-21. [Content Brief]

[3]. Wang J, et al. Discovery of multi-target receptor tyrosine kinase inhibitors as novel anti-angiogenesis agents. Sci Rep. 2017 Mar 23;7:45145. [Content Brief]

[4]. Bollenbach M, et al. Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model. Molecules. 2021 Jan 13;26(2):391. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.7799 mL	28.8996 mL	57.7991 mL	144.4978 mL
	5 mM	1.1560 mL	5.7799 mL	11.5598 mL	28.8996 mL
	10 mM	0.5780 mL	2.8900 mL	5.7799 mL	14.4498 mL
	15 mM	0.3853 mL	1.9266 mL	3.8533 mL	9.6332 mL
	20 mM	0.2890 mL	1.4450 mL	2.8900 mL	7.2249 mL
	25 mM	0.2312 mL	1.1560 mL	2.3120 mL	5.7799 mL
	30 mM	0.1927 mL	0.9633 mL	1.9266 mL	4.8166 mL
	40 mM	0.1445 mL	0.7225 mL	1.4450 mL	3.6124 mL
	50 mM	0.1156 mL	0.5780 mL	1.1560 mL	2.8900 mL
	60 mM	0.0963 mL	0.4817 mL	0.9633 mL	2.4083 mL
	80 mM	0.0722 mL	0.3612 mL	0.7225 mL	1.8062 mL
	100 mM	0.0578 mL	0.2890 mL	0.5780 mL	1.4450 mL