2. Anti-infection
  3. Bacterial Antibiotic
  4. SPR741

SPR741 (NAB741) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

SPR741 Chemical Structure

SPR741 Chemical Structure

CAS No. : 1179330-52-9

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Based on 3 publication(s) in Google Scholar

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SPR741 Related Antibodies

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Description

SPR741 (NAB741) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741[1][2].

In Vitro

SPR741 potentiates antibiotics that are substrates of the AcrAB-TolC efflux pump in E. coli, effectively circumventing the contribution of this pump to intrinsic antibiotic resistance. The intrinsic resistance of E. coli to certain antibiotics that is mediated by both the outer membrane and the AcrAB-TolC efflux system can be overcome, or circumvented, by combining the antibiotic with SPR741 but that potentiation of intrinsic resistance due primarily to efflux may be limited[1].
SPR741 lacks significant antibacterial activity as a stand-alone agent but interacts with the outer membrane of Gram-negative bacteria to increase permeability and thereby improve the accumulation of coadministered antibiotics inside the pathogen[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SPR741 Related Antibodies
In Vivo

SPR741 has the ability to permeabilize the outer membrane of Gram-negative bacteria, thus sensitizing them to hydrophobic antibiotics. SPR741 has a significantly safety profile of compared to that of polymyxin B, which suffers severe, dose-limiting nephrotoxicity in humans. In multiday rodent and nonhuman primate studies, polymyxin B exhibited nephrotoxicity at a far-lower exposure-normalized dose than SPR741[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

992.13

Formula

C44H73N13O13
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (100.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0079 mL 5.0397 mL 10.0793 mL
5 mM 0.2016 mL 1.0079 mL 2.0159 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0079 mL 5.0397 mL 10.0793 mL 25.1983 mL
5 mM 0.2016 mL 1.0079 mL 2.0159 mL 5.0397 mL
10 mM 0.1008 mL 0.5040 mL 1.0079 mL 2.5198 mL
15 mM 0.0672 mL 0.3360 mL 0.6720 mL 1.6799 mL
20 mM 0.0504 mL 0.2520 mL 0.5040 mL 1.2599 mL
25 mM 0.0403 mL 0.2016 mL 0.4032 mL 1.0079 mL
30 mM 0.0336 mL 0.1680 mL 0.3360 mL 0.8399 mL
40 mM 0.0252 mL 0.1260 mL 0.2520 mL 0.6300 mL
50 mM 0.0202 mL 0.1008 mL 0.2016 mL 0.5040 mL
60 mM 0.0168 mL 0.0840 mL 0.1680 mL 0.4200 mL
80 mM 0.0126 mL 0.0630 mL 0.1260 mL 0.3150 mL
100 mM 0.0101 mL 0.0504 mL 0.1008 mL 0.2520 mL
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SPR741 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPR7411179330-52-9NAB741SPR 741SPR-741NAB 741NAB-741BacterialAntibioticPotentiatorGram-negativeantibioticcombinationmembranepermeabilityAcrAB-TolCeffluxpumpmultidrug-resistantInhibitorinhibitorinhibit

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