Sox10 - SRY (sex determining region Y)-box 10 Gene

Mus musculus

Also known as gt; Dom; Sox21

Gene ID: 20665 | Gene type: protein coding

About Sox10

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; neural crest cell migration; and neurogenesis. Acts upstream of or within several processes, including lacrimal gland development; melanocyte differentiation; and nervous system development. Located in cytoplasm and nucleus. Is extrinsic component of mitochondrial outer membrane. Is expressed in several structures, including alimentary system; genitourinary system; inner ear; mesenchyme derived from neural crest; and nervous system. Used to study Kallmann syndrome; PCWH syndrome; and Waardenburg syndrome type 4C. Human ortholog(s) of this gene implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome type 2E; and Waardenburg syndrome type 4C. Orthologous to human SOX10 (SRY-box transcription factor 10). [provided by Alliance of Genome Resources, Apr 2022]

Sox10 Products(1)

mRNA	Protein	Name
NM_011437.1	NP_035567.1	transcription factor SOX-10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	24204311	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	24204311	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	17084361	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15729346	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15102707	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15729346	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19304657	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	17084361	MGI
enables transcription factor binding	IDA IDA: Inferred from direct assay	19179536	MGI
enables transcription factor binding	IGI IGI: Inferred from genetic interaction	23575864	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell differentiation	IMP IMP: Inferred from mutant phenotype	11799060	MGI
acts upstream of or within cell maturation	IGI IGI: Inferred from genetic interaction	15102707	MGI
acts upstream of or within cell maturation	IMP IMP: Inferred from mutant phenotype	15102707	MGI
involved in central nervous system myelination	IMP IMP: Inferred from mutant phenotype	24204311	MGI
acts upstream of or within developmental growth	IMP IMP: Inferred from mutant phenotype	16790476	MGI
acts upstream of or within digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	6512238	MGI
acts upstream of or within enteric nervous system development	IMP IMP: Inferred from mutant phenotype	6512238	MGI
involved in enteric nervous system development	IMP IMP: Inferred from mutant phenotype	15572147	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	16790476	MGI
acts upstream of or within lacrimal gland development	IMP IMP: Inferred from mutant phenotype	24924191	MGI
acts upstream of or within melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	16790476	MGI
acts upstream of or within morphogenesis of a branching epithelium	IGI IGI: Inferred from genetic interaction	24924191	MGI
acts upstream of or within morphogenesis of a branching epithelium	IMP IMP: Inferred from mutant phenotype	24924191	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15572147	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17875931	MGI
involved in neural crest cell migration	IMP IMP: Inferred from mutant phenotype	15572147	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	16857183	MGI
involved in oligodendrocyte development	IMP IMP: Inferred from mutant phenotype	24204311	MGI
acts upstream of or within oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	16790476	MGI
involved in oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	24204311	MGI
acts upstream of or within peripheral nervous system development	IGI IGI: Inferred from genetic interaction	16790476	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21610032	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17084361	MGI
involved in positive regulation of gliogenesis	IMP IMP: Inferred from mutant phenotype	15572147	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	16857183	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19304657	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15729346	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16857183	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16857183	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19304657	MGI
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	19304657	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15572147	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor SOX-10

SRY-box containing gene 10	dominant megacolon
transcription factor SOX-M

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13583	SOX10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18684	Sox10 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25170	Sox10 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sox10	NCBI	NCBI:6663

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