Sorl1 - sortilin-related receptor, LDLR class A repeats-containing Gene

Mus musculus

Also known as LR11; SorLA; gp250; mSorLA; 2900010L19Rik

Gene ID: 20660 | Gene type: protein coding

About Sorl1

Summary

Predicted to enable several functions, including low-density lipoprotein particle binding activity; peptide binding activity; and small GTPase binding activity. Involved in several processes, including diet induced thermogenesis; negative regulation of protein metabolic process; and regulation of signal transduction. Located in extracellular space; nuclear envelope lumen; and perinucleolar compartment. Is integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SORL1 (sortilin related receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sorl1 Products(2)

mRNA	Protein	Name
NM_001357261.1	NP_001344190.1	sortilin-related receptor isoform 2
NM_011436.4	NP_035566.2	sortilin-related receptor isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aspartic-type endopeptidase inhibitor activity	IMP IMP: Inferred from mutant phenotype	18362153	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16407538	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in adaptive thermogenesis	IMP IMP: Inferred from mutant phenotype	26584636	MGI
involved in diet induced thermogenesis	IMP IMP: Inferred from mutant phenotype	26584636	MGI
involved in endosome to plasma membrane protein transport	IDA IDA: Inferred from direct assay	27322061	MGI
involved in insulin receptor recycling	IDA IDA: Inferred from direct assay	27322061	MGI
involved in negative regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	26584636	MGI
involved in negative regulation of amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	18362153	MGI
involved in negative regulation of amyloid-beta formation	IMP IMP: Inferred from mutant phenotype	18362153	MGI
involved in negative regulation of neurofibrillary tangle assembly	IMP IMP: Inferred from mutant phenotype	22986780	MGI
involved in negative regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	18362153	MGI
involved in negative regulation of triglyceride catabolic process	IMP IMP: Inferred from mutant phenotype	27322061	MGI
involved in positive regulation of adipose tissue development	IMP IMP: Inferred from mutant phenotype	27322061	MGI
involved in positive regulation of glial cell-derived neurotrophic factor production	IMP IMP: Inferred from mutant phenotype	21994944	MGI
involved in positive regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	27322061	MGI
involved in protein retention in Golgi apparatus	IMP IMP: Inferred from mutant phenotype	18362153	MGI
involved in protein targeting	IDA IDA: Inferred from direct assay	27322061	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	11082041	MGI
located in membrane	IDA IDA: Inferred from direct assay	11082041	MGI
located in nuclear envelope lumen	IDA IDA: Inferred from direct assay	18362153	MGI
located in perinucleolar compartment	IDA IDA: Inferred from direct assay	11082041	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sortilin-related receptor

LDLR relative with 11 ligand-binding repeats	low-density lipoprotein receptor relative with 11 ligand-binding repeats
sorLA-1	sorting protein-related receptor containing LDLR class A repeats

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13574	SORL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21763	Sorl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sorl1	NCBI	NCBI:6653

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