Snai1 - snail family zinc finger 1 Gene

Mus musculus

Also known as Sna; Sna1; Snail; Snail1

Gene ID: 20613 | Gene type: protein coding

About Snai1

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including heart development; positive regulation of epithelial to mesenchymal transition; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; left/right pattern formation; and negative regulation of cell differentiation involved in embryonic placenta development. Located in cytoplasm; nucleus; and pericentric heterochromatin. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and sensory organ. Used to study dilated cardiomyopathy and skin Cancer. Orthologous to human SNAI1 (snail family transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Snai1 Products(1)

mRNA	Protein	Name
NM_011427.3	NP_035557.1	zinc finger protein SNAI1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12917416	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12917416	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18331720	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9676199	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Notch signaling pathway	IGI IGI: Inferred from genetic interaction	20890042	MGI
acts upstream of or within cartilage morphogenesis	IGI IGI: Inferred from genetic interaction	17376812	MGI
acts upstream of or within epithelial cell migration	IGI IGI: Inferred from genetic interaction	17376812	MGI
involved in epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	10655586	MGI
involved in epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	11689706	MGI
involved in epithelial to mesenchymal transition involved in endocardial cushion formation	IGI IGI: Inferred from genetic interaction	18663143	MGI
acts upstream of or within hair follicle morphogenesis	IDA IDA: Inferred from direct assay	15630473	MGI
involved in heterochromatin organization	IMP IMP: Inferred from mutant phenotype	24239292	MGI
acts upstream of or within left/right pattern formation	IMP IMP: Inferred from mutant phenotype	16801545	MGI
acts upstream of or within mesoderm development	IMP IMP: Inferred from mutant phenotype	16801545	MGI
involved in mesoderm formation	IMP IMP: Inferred from mutant phenotype	11689706	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10655586	MGI
acts upstream of or within negative regulation of cell differentiation involved in embryonic placenta development	IDA IDA: Inferred from direct assay	9676199	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9676199	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12917416	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10655586	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12832491	MGI
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20890042	MGI
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	20890042	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9676199	MGI
acts upstream of or within roof of mouth development	IGI IGI: Inferred from genetic interaction	17376812	MGI
acts upstream of or within trophoblast giant cell differentiation	IDA IDA: Inferred from direct assay	9676199	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12832491	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12832491	MGI
located in pericentric heterochromatin	IDA IDA: Inferred from direct assay	24239292	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zinc finger protein SNAI1

snail homolog 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10456	TAK-715		99.76%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13470	SNAI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P5291	CPF-7		/	Unkown
HY-RS19742	Snai1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26238	Snai1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Snai1	NCBI	NCBI:6615

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