Vps4b - vacuolar protein sorting 4B Gene

Mus musculus

Also known as Skd1; 8030489C12Rik

Gene ID: 20479 | Gene type: protein coding

About Vps4b

Summary

Predicted to enable ATP hydrolysis activity; protein C-terminus binding activity; and protein homodimerization activity. Involved in late endosomal microautophagy; multivesicular body assembly; and viral budding from plasma membrane. Acts upstream of or within Cholesterol transport; endosome organization; and potassium ion transport. Located in cytosol. Orthologous to human VPS4B (vacuolar protein sorting 4 homolog B). [provided by Alliance of Genome Resources, Apr 2022]

Vps4b Products(1)

mRNA	Protein	Name
NM_009190.2	NP_033216.2	vacuolar protein sorting-associated protein 4B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12594041	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	28675177	MGI
acts upstream of or within canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	28675177	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	28675177	MGI
acts upstream of or within cholesterol transport	IMP IMP: Inferred from mutant phenotype	10637304	MGI
acts upstream of or within endosome organization	IGI IGI: Inferred from genetic interaction	26720614	MGI
acts upstream of or within endosome organization	IMP IMP: Inferred from mutant phenotype	10637304	MGI
acts upstream of or within establishment of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	28675177	MGI
involved in late endosomal microautophagy	IMP IMP: Inferred from mutant phenotype	21238931	MGI
involved in multivesicular body assembly	IMP IMP: Inferred from mutant phenotype	21238931	MGI
acts upstream of or within potassium ion transport	IDA IDA: Inferred from direct assay	8082782	MGI
acts upstream of or within vacuolar transport	IMP IMP: Inferred from mutant phenotype	28675177	MGI
involved in viral budding from plasma membrane	IMP IMP: Inferred from mutant phenotype	17940959	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	10637304	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vacuolar protein sorting-associated protein 4B

suppressor of K(+) transport growth defect 1

suppressor of K+ transport defect 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123872	MSC1094308	Inhibitor	99.89%	Unkown
HY-RS15694	VPS4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20516	Vps4b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27025	Vps4b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vps4b	NCBI	NCBI:9525

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