Spi1 - spleen focus forming virus (SFFV) proviral integration oncogene Gene

Also known as Dis1; PU.1; Dis-1; Sfpi1; Spi-1; Sfpi-1; Tcfpu1; Tfpu.1

About Spi1

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding activity; and histone deacetylase binding activity. Involved in several processes, including lymphocyte differentiation; regulation of gene expression; and regulation of myeloid leukocyte mediated immunity. Acts upstream of or within several processes, including apoptotic process involved in blood vessel morphogenesis; hemopoiesis; and regulation of transcription, DNA-templated. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Used to study acute myeloid leukemia. Orthologous to human SPI1 (Spi-1 proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]