CELA1 - chymotrypsin like elastase 1 Gene

Homo sapiens

Also known as ELA1

Gene ID: 1990 | Gene type: protein coding

About CELA1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:51,328,442-51,346,679 (from NCBI)

This gene has 1 transcript (splice variant), 325 orthologues and 6 paralogues. Low expression observed in reference dataset.

Summary

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six Elastase genes which encode the structurally similar proteins Elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike Other elastases, pancreatic Elastase 1 is not expressed in the pancreas. To date, Elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human Elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like Elastase family, member 3B. [provided by RefSeq, May 2009]

CELA1 Products(1)

mRNA	Protein	Name
NM_001971.6	NP_001962.3	chymotrypsin-like elastase family member 1

CELA1 Protein Structure

Trypsin

0
100
200
258 a.a.

Protein Preferred Names

Protein Names

chymotrypsin-like elastase family member 1

chymotrypsin like elastase family member 1

Related Diseases

Diseases

Alias

Pancreatic Steatorrhea

Pancreatic Steatorrhoea	Decreased Tolerance Of Pancreas
Pancreatic Disturbance Of Fat Absorption

Pancreatic Acinar Cell Adenocarcinoma

Pancreatic Acinar Cell Carcinoma

Acinar Cell Adenocarcinoma Of The Pancreas

Autoimmune Pancreatitis

Lymphoplasmocytic Sclerosing Pancreatitis

Aip

Exocrine Pancreatic Insufficiency

Biliary Dyskinesia

Sphincter Of Oddi Dysfunction

Acute Necrotizing Pancreatitis

Pancreatitis, Acute Necrotizing

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02455	CELA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CELA1	VGNC	VGNC:27166
Macaca mulatta	CELA1	VGNC	VGNC:71152
Felis catus	CELA1	VGNC	VGNC:60743
Canis familiaris	CELA1	VGNC	VGNC:39092
Mus musculus	CELA1	MGD	MGI:95314
Rattus norvegicus	CELA1	RGD	RGD:2547

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