Rheb - Ras homolog enriched in brain Gene

Mus musculus

Also known as Rheb1

Gene ID: 19744 | Gene type: protein coding

About Rheb

Summary

Enables GTP binding activity and protein kinase binding activity. Involved in negative regulation of cold-induced thermogenesis and positive regulation of TOR signaling. Acts upstream of or within positive regulation of oligodendrocyte differentiation. Part of spliceosomal complex. Is expressed in chondrocranium bone; nervous system; nucleus pulposus; and sensory organ. Orthologous to human RHEB (Ras homolog, mTORC1 binding). [provided by Alliance of Genome Resources, Apr 2022]

Rheb Products(1)

mRNA	Protein	Name
NM_053075.3	NP_444305.2	GTP-binding protein Rheb

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	21336308	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21336308	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	28242620	MGI
acts upstream of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	25411504	MGI
involved in positive regulation of TOR signaling	IDA IDA: Inferred from direct assay	21336308	MGI
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	12820960	MGI
involved in positive regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	21321084	MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	25411504	MGI
involved in regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	19258434	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Golgi membrane	IDA IDA: Inferred from direct assay	16631613	MGI
is active in endomembrane system	IDA IDA: Inferred from direct assay	16631613	MGI
part of spliceosomal complex	IDA IDA: Inferred from direct assay	11555636	MGI
is active in synapse	EXP EXP: Inferred from Experiment	25211037	MGI
is active in synapse	IDA IDA: Inferred from direct assay	25211037	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

GTP-binding protein Rheb

RAS-homolog enriched in brain

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14530	Pelitrexol		98.94%	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124798	Rheb inhibitor NR1	Inhibitor	99.26%	Unkown
HY-RS11942	RHEB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17646	Rheb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24106	Rheb Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rheb	NCBI	NCBI:6009

Name
Email *

	Sorry, but the email address you supplied was invalid.