Qki - quaking, KH domain containing RNA binding Gene

Mus musculus

Also known as Qk; l17Wis1; 1500005P18; l(17)-1Wis; 1110003F05Rik

Gene ID: 19317 | Gene type: protein coding

About Qki

Summary

Enables mRNA binding activity. Acts upstream of or within several processes, including long-chain fatty acid biosynthetic process; positive regulation of macromolecule metabolic process; and vasculogenesis. Located in cytoplasm; nucleus; and synapse. Is expressed in several structures, including alimentary system; central nervous system; craniocervical region bone; reproductive system; and sensory organ. Orthologous to human QKI (QKI, KH domain containing RNA binding). [provided by Alliance of Genome Resources, Apr 2022]

Qki Products(3)

mRNA	Protein	Name
NM_001159516.2	NP_001152988.1	protein quaking isoform 2
NM_001159517.2	NP_001152989.1	protein quaking isoform 1
NM_021881.3	NP_068681.1	protein quaking isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	21253564	MGI
enables mRNA 3'-UTR binding	IMP IMP: Inferred from mutant phenotype	31868295	MGI
enables mRNA binding	IDA IDA: Inferred from direct assay	20956316	MGI
enables mRNA binding	IMP IMP: Inferred from mutant phenotype	36627242	MGI
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	33942715	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon ensheathment	IMP IMP: Inferred from mutant phenotype	14169723	MGI
acts upstream of or within long-chain fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	1150661	MGI
involved in mRNA stabilization	IDA IDA: Inferred from direct assay	32732889	MGI
involved in microglia differentiation	IMP IMP: Inferred from mutant phenotype	33378678	MGI
acts upstream of or within myelination	IMP IMP: Inferred from mutant phenotype	1150661	MGI
involved in myofibroblast contraction	IMP IMP: Inferred from mutant phenotype	33397958	MGI
involved in negative regulation of 3'-UTR-mediated mRNA stabilization	IMP IMP: Inferred from mutant phenotype	31868295	MGI
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	32732889	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	31868295	MGI
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	20956316	MGI
involved in negative regulation of translation	IMP IMP: Inferred from mutant phenotype	31868295	MGI
involved in positive regulation of 3'-UTR-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	28188285	MGI
involved in positive regulation of cholesterol biosynthetic process	IMP IMP: Inferred from mutant phenotype	33942715	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	1373175	MGI
involved in positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	33942715	MGI
involved in positive regulation of oligodendrocyte differentiation	IDA IDA: Inferred from direct assay	20956316	MGI
involved in regulation of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	33750804	MGI
involved in regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	29021242	MGI
involved in regulation of mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	33378678	MGI
acts upstream of or within spermatid development	IGI IGI: Inferred from genetic interaction	15148410	MGI
involved in spliceosome-depend formation of circular RNA	IDA IDA: Inferred from direct assay	37272356	MGI
acts upstream of or within vascular associated smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	14706070	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	11892011	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	20956316	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10506177	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	28188285	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10506177	MGI
is active in nucleus	IMP IMP: Inferred from mutant phenotype	31868295	MGI
located in nucleus	IMP IMP: Inferred from mutant phenotype	10506177	MGI
is active in synapse	EXP EXP: Inferred from Experiment	16452087	MGI
is active in synapse	IDA IDA: Inferred from direct assay	16452087	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein quaking

QKI-5 protein	QKI-6 protein
QKI-7 protein	QKI-7b protein
lethal, Chr 17, U Wisconsin 1	quaking

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS21287	Qki Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11500	QKI Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Qki	NCBI	NCBI:9444

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