Ptk2b - PTK2 protein tyrosine kinase 2 beta Gene

Mus musculus

Also known as CAKB; FAK2; PYK2; CADTK; FADK2; Raftk; CAKbeta; E430023O05Rik

Gene ID: 19229 | Gene type: protein coding

About Ptk2b

Summary

Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including regulation of cell migration; regulation of intracellular signal transduction; and regulation of phosphate metabolic process. Acts upstream of or within cellular response to fluid shear stress and protein phosphorylation. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including blastocyst; early embryo; gonad; gonad primordium; and heart. Human ortholog(s) of this gene implicated in breast Cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta). [provided by Alliance of Genome Resources, Apr 2022]

Ptk2b Products(4)

mRNA	Protein	Name
NM_001162365.1	NP_001155837.1	protein-tyrosine kinase 2-beta isoform 2
NM_001162366.2	NP_001155838.1	protein-tyrosine kinase 2-beta isoform 1
NM_001360233.1	NP_001347162.1	protein-tyrosine kinase 2-beta isoform 1
NM_172498.3	NP_766086.2	protein-tyrosine kinase 2-beta isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	17537919	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11238453	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	11274221	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in bone resorption	IMP IMP: Inferred from mutant phenotype	14739300	MGI
acts upstream of or within cellular response to fluid shear stress	IMP IMP: Inferred from mutant phenotype	24841674	MGI
involved in chemokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12960403	MGI
involved in cortical cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	12960403	MGI
involved in marginal zone B cell differentiation	IMP IMP: Inferred from mutant phenotype	10881171	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19880522	MGI
involved in negative regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	17537919	MGI
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	17537919	MGI
involved in positive regulation of B cell chemotaxis	IMP IMP: Inferred from mutant phenotype	10881171	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	17698736	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19880522	MGI
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	17698736	MGI
acts upstream of positive effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	12960403	MGI
involved in positive regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	19880522	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	11274221	MGI
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	12960403	MGI
involved in regulation of macrophage chemotaxis	IMP IMP: Inferred from mutant phenotype	12960403	MGI
involved in regulation of postsynaptic density assembly	IDA IDA: Inferred from direct assay	28555636	MGI
involved in regulation of postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	28555636	MGI
involved in regulation of release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	12960403	MGI
involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	21640103	MGI
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17698736	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28555636	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	28555636	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19880522	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	24841674	MGI
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	28555636	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	28555636	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein-tyrosine kinase 2-beta

CAK-beta	calcium-dependent tyrosine kinase
calcium-regulated non-receptor proline-rich tyrosine kinase	cell adhesion kinase beta
cellular adhesion kinase beta	focal adhesion kinase 2
proline-rich tyrosine kinase 2	related adhesion focal tyrosine ki

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148063	DB0614		98.80%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-RS11402	PTK2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20473	Ptk2b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26981	Ptk2b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptk2b	NCBI	NCBI:2185

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