Ptgs2 - prostaglandin-endoperoxide synthase 2 Gene

Mus musculus

Also known as COX2; Cox-2; PES-2; PHS-2; Pghs2; TIS10; PGHS-2; PHS II; gripghs

Gene ID: 19225 | Gene type: protein coding

About Ptgs2

Summary

This gene encodes an enzyme that is a member of the prostaglandin G/H synthase family. The encoded protein converts arachidonic acid to prostaglandin endoperoxide H2 which is a key enzymatic step in prostaglandin biosynthesis. This gene is the inducible prostaglandin G/H synthase family member that is upregulated during inflammation. Aberrant regulation of this gene is associated with Cancer progression in several tissues and an increased risk of cardiovascular events. This gene is the target of many non-steroidal anti-inflammatory drugs. [provided by RefSeq, Sep 2015]

Ptgs2 Products(1)

mRNA	Protein	Name
NM_011198.5	NP_035328.2	prostaglandin G/H synthase 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heme binding	IDA IDA: Inferred from direct assay	12925531	MGI
enables prostaglandin-endoperoxide synthase activity	IDA IDA: Inferred from direct assay	1419907	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18650379	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	12925531	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anagen	IMP IMP: Inferred from mutant phenotype	15713628	MGI
involved in brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	20448152	MGI
acts upstream of or within cellular response to fluid shear stress	IDA IDA: Inferred from direct assay	24841674	MGI
involved in cellular response to non-ionic osmotic stress	IMP IMP: Inferred from mutant phenotype	21716255	MGI
acts upstream of or within cyclooxygenase pathway	IDA IDA: Inferred from direct assay	1419907	MGI
involved in cyclooxygenase pathway	IDA IDA: Inferred from direct assay	12925531	MGI
acts upstream of or within decidualization	IMP IMP: Inferred from mutant phenotype	10385625	MGI
acts upstream of or within embryo implantation	IMP IMP: Inferred from mutant phenotype	10385625	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21716255	MGI
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	21716255	MGI
involved in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	IMP IMP: Inferred from mutant phenotype	21716255	MGI
involved in positive regulation of brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	20448152	MGI
involved in positive regulation of fever generation	IDA IDA: Inferred from direct assay	19940926	MGI
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	21716255	MGI
involved in positive regulation of prostaglandin biosynthetic process	IMP IMP: Inferred from mutant phenotype	21716255	MGI
involved in prostaglandin biosynthetic process	IDA IDA: Inferred from direct assay	12925531	MGI
acts upstream of or within prostaglandin secretion	IMP IMP: Inferred from mutant phenotype	32484881	MGI
acts upstream of or within regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	12093889	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	8945508	MGI
involved in regulation of neuroinflammatory response	IDA IDA: Inferred from direct assay	29662056	MGI
acts upstream of or within response to nematode	IDA IDA: Inferred from direct assay	26644468	MGI
acts upstream of or within response to nematode	IMP IMP: Inferred from mutant phenotype	32484881	MGI
acts upstream of or within response to selenium ion	IDA IDA: Inferred from direct assay	26644468	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12021206	MGI
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	21716255	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	12355421	MGI
located in nuclear inner membrane	IDA IDA: Inferred from direct assay	9545330	MGI
located in nuclear outer membrane	IDA IDA: Inferred from direct assay	9545330	MGI
NOT located in nucleus	IDA IDA: Inferred from direct assay	12021206	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

prostaglandin G/H synthase 2

PGH synthase 2	cyclooxygenase-2
glucocorticoid-regulated inflammatory cyclooxygenase	macrophage activation-associated marker protein P71/73
prostaglandin H2 synthase 2

Ptgs2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82796	Cyclooxygenase 2 Antibody (YA2541)	WB, ICC/IF, IP	Mouse

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6929	Angelic acid		99.20%	Unkown
HY-121025	BUR1	Inhibitor	99.65%	Unkown
HY-RS11393	PTGS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16902	Ptgs2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23344	Ptgs2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptgs2	NCBI	NCBI:5743

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