Ptf1a - pancreas specific transcription factor, 1a Gene

Mus musculus

Also known as PTF1p48; bHLHa29; PTF1-p48

Gene ID: 19213 | Gene type: protein coding

About Ptf1a

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in several processes, including neural retina development; regulation of neural retina development; and retinoic acid receptor signaling pathway. Acts upstream of or within several processes, including pancreas development; positive regulation of transcription by RNA polymerase II; and retina morphogenesis in camera-type eye. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; epidermis; eye; foregut-midgut junction; and genitourinary system. Human ortholog(s) of this gene implicated in pancreatic agenesis. Orthologous to human PTF1A (pancreas associated transcription factor 1a). [provided by Alliance of Genome Resources, Apr 2022]

Ptf1a Products(1)

mRNA	Protein	Name
NM_018809.2	NP_061279.2	pancreas transcription factor 1 subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	2294404	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19887377	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	22232429	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	23639443	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11318877	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17938243	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within amacrine cell differentiation	IMP IMP: Inferred from mutant phenotype	17301087	MGI
involved in amacrine cell differentiation	IMP IMP: Inferred from mutant phenotype	17075007	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	12185368	MGI
involved in cerebellum development	IMP IMP: Inferred from mutant phenotype	15543146	MGI
involved in generation of neurons	IDA IDA: Inferred from direct assay	11318877	MGI
acts upstream of or within generation of neurons	IMP IMP: Inferred from mutant phenotype	23616538	MGI
involved in hindbrain development	IDA IDA: Inferred from direct assay	11318877	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	17301087	MGI
acts upstream of or within neuron fate commitment	IDA IDA: Inferred from direct assay	16039563	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	17938243	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17938243	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11279116	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19887377	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19887377	MGI
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15543146	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	9851981	MGI
involved in regulation of neural retina development	IMP IMP: Inferred from mutant phenotype	17075007	MGI
involved in retina layer formation	IMP IMP: Inferred from mutant phenotype	17075007	MGI
acts upstream of or within retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	17301087	MGI
involved in retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	11318877	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23639443	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19887377	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	17938243	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	17938243	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pancreas transcription factor 1 subunit alpha

bHLH transcription factor p48	p48 DNA-binding subunit of transcription factor PTF1
pancreas transcription factor1 p48 subunit

Ptf1a Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81962	PTF1A Antibody (YA1707)	WB, IP	Human, Rat

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11367	PTF1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptf1a	NCBI	NCBI:256297

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