2. Gene
  3. Prps1 - phosphoribosyl pyrophosphate synthetase 1 Gene

Prps1 - phosphoribosyl pyrophosphate synthetase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PRS-I; Prps-1; 2310010D17Rik

Gene ID: 19139 | Gene type: protein coding

About Prps1

Summary

Predicted to enable ATP binding activity; protein homodimerization activity; and ribose phosphate diphosphokinase activity. Predicted to be involved in several processes, including 5-phosphoribose 1-diphosphate biosynthetic process; purine-containing compound biosynthetic process; and urate biosynthetic process. Predicted to act upstream of or within nucleotide biosynthetic process and phosphorylation. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Is expressed in central nervous system; inner ear; and retina. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Prps1 Products(1)

mRNA Protein Name
NM_021463.4 NP_067438.1 ribose-phosphate pyrophosphokinase 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ribose phosphate diphosphokinase activity IDA
IDA: Inferred from direct assay
26175007 MGI
Biological Process GO Annotation Evidence Reference Source
involved in 5-phosphoribose 1-diphosphate biosynthetic process IDA
IDA: Inferred from direct assay
26175007 MGI
involved in pentose-phosphate shunt IMP
IMP: Inferred from mutant phenotype
24855946 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in cytosol IDA
IDA: Inferred from direct assay
30379953 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ribose-phosphate pyrophosphokinase 1

phosphoribosyl pyrophosphate synthase I

phosphoribosyl pyrophosphate synthetase I

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-128345 UDM-001651 Antagonist / Unkown
HY-RS11219 PRPS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18677 Prps1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25163 Prps1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prps1 NCBI NCBI:5631