Pou4f1 - POU domain, class 4, transcription factor 1 Gene

Mus musculus

Also known as Brn3; Brn-3; Brn3a; Brn3.0; Brn-3.0; E130119J07Rik

Gene ID: 18996 | Gene type: protein coding

About Pou4f1

Summary

Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and GTPase binding activity. Involved in several processes, including cellular response to estradiol stimulus; nervous system development; and regulation of gene expression. Acts upstream of or within several processes, including nervous system development; proprioception involved in equilibrioception; and suckling behavior. Located in several cellular components, including chromatin; neuron projection; and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch mesenchyme; central nervous system; future brain; ganglia; and retina. Orthologous to human POU4F1 (POU class 4 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Pou4f1 Products(1)

mRNA	Protein	Name
NM_011143.4	NP_035273.3	POU domain, class 4, transcription factor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12810599	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10329733	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	18421303	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	12810599	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	12810599	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20096094	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	18421303	MGI
enables GTPase binding	IPI IPI: Inferred from physical interaction	12934100	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12810599	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18421303	MGI
enables chromatin binding	IGI IGI: Inferred from genetic interaction	12934100	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8537352	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7935408	MGI
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	8621561	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell migration in hindbrain	IMP IMP: Inferred from mutant phenotype	8955272	MGI
involved in cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	17668438	MGI
involved in cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	9448000	MGI
acts upstream of or within central nervous system neuron differentiation	IMP IMP: Inferred from mutant phenotype	8876243	MGI
acts upstream of or within habenula development	IMP IMP: Inferred from mutant phenotype	19906978	MGI
involved in heart development	IGI IGI: Inferred from genetic interaction	28594399	MGI
acts upstream of or within innervation	IMP IMP: Inferred from mutant phenotype	19906978	MGI
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17145718	MGI
acts upstream of or within mesoderm development	IMP IMP: Inferred from mutant phenotype	19877281	MGI
acts upstream of negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	18421303	MGI
involved in negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	12203124	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28594399	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20096094	MGI
involved in negative regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	17145718	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19877281	MGI
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18421303	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19877281	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17239249	MGI
acts upstream of or within nervous system development	IDA IDA: Inferred from direct assay	12810599	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	15492043	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	16040009	MGI
involved in neuron fate specification	IMP IMP: Inferred from mutant phenotype	19877281	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	8955272	MGI
involved in neuron projection development	IDA IDA: Inferred from direct assay	8972215	MGI
acts upstream of or within peripheral nervous system neuron development	IGI IGI: Inferred from genetic interaction	21734270	MGI
involved in peripheral nervous system neuron development	IMP IMP: Inferred from mutant phenotype	17239249	MGI
acts upstream of or within peripheral nervous system neuron differentiation	IMP IMP: Inferred from mutant phenotype	8876243	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	8972215	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	15492043	MGI
involved in positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	17668438	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10329733	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	12934100	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19877281	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	7935408	MGI
involved in positive regulation of transcription regulatory region DNA binding	IDA IDA: Inferred from direct assay	9448000	MGI
acts upstream of or within proprioception involved in equilibrioception	IMP IMP: Inferred from mutant phenotype	8876243	MGI
involved in regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9448000	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12810599	MGI
acts upstream of regulation of cell cycle	IGI IGI: Inferred from genetic interaction	12203124	MGI
acts upstream of negative effect regulation of cell cycle	IGI IGI: Inferred from genetic interaction	18421303	MGI
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	17145718	MGI
acts upstream of or within regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	19877281	MGI
involved in sensory system development	IMP IMP: Inferred from mutant phenotype	20096094	MGI
acts upstream of or within suckling behavior	IMP IMP: Inferred from mutant phenotype	8876243	MGI
involved in trigeminal nerve development	IMP IMP: Inferred from mutant phenotype	19877281	MGI
involved in ventricular compact myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	18368538	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	10329733	MGI
located in chromatin	IDA IDA: Inferred from direct assay	17196582	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17668438	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	19906978	MGI
located in nucleus	IDA IDA: Inferred from direct assay	7623109	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

POU domain, class 4, transcription factor 1

brain-3A	brain-specific homeobox/POU domain protein 3A
brn-3A

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10904	POU4F1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21173	Pou4f1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pou4f1	NCBI	NCBI:5457

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