2. Gene
  3. Abcb1b - ATP-binding cassette, sub-family B (MDR/TAP), member 1B Gene

Abcb1b - ATP-binding cassette, sub-family B (MDR/TAP), member 1B Gene

  • Gene
  • Protein
Mus musculus

Also known as mdr; Mdr1; Pgy1; Abcb1; Mdr1b; Pgy-1

Gene ID: 18669 | Gene type: protein coding

About Abcb1b

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene encodes a membrane glycoprotein which confers a multidrug-resistance phenotype. The protein encoded by the human gene is an ATP-dependent drug efflux pump for xenobiotic compounds which is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to Anticancer drugs. [provided by RefSeq, Jul 2008]

Abcb1b Products(1)

mRNA Protein Name
NM_011075.2 NP_035205.1 ATP-dependent translocase ABCB1
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in intercellular canaliculus IDA
IDA: Inferred from direct assay
12068294 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-dependent translocase ABCB1

ATP-binding cassette sub-family B member 1

P glycoprotein 1

multidrug resistance protein 1

multidrug resistance protein 1B

phospholipid transporter ABCB1