Pdk2 - pyruvate dehydrogenase kinase, isoenzyme 2 Gene

Mus musculus

Gene ID: 18604 | Gene type: protein coding

About Pdk2

Summary

Enables pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in several processes, including Insulin Receptor signaling pathway; regulation of acetyl-CoA biosynthetic process from pyruvate; and regulation of gluconeogenesis. Acts upstream of or within regulation of calcium-mediated signaling. Located in mitochondrion. Part of mitochondrial pyruvate dehydrogenase complex. Is expressed in heart. Orthologous to human PDK2 (pyruvate dehydrogenase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Pdk2 Products(2)

mRNA	Protein	Name
NM_001361915.1	NP_001348844.1	pyruvate dehydrogenase kinase, isoenzyme 2 isoform 2
NM_133667.2	NP_598428.2	pyruvate dehydrogenase kinase, isoenzyme 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	IMP IMP: Inferred from mutant phenotype	22360721	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to nutrient	IMP IMP: Inferred from mutant phenotype	22360721	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	22360721	MGI
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22360721	MGI
involved in regulation of acetyl-CoA biosynthetic process from pyruvate	IMP IMP: Inferred from mutant phenotype	22360721	MGI
acts upstream of or within regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	23357539	MGI
involved in regulation of cellular ketone metabolic process	IMP IMP: Inferred from mutant phenotype	22360721	MGI
involved in regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	22360721	MGI
involved in regulation of glucose metabolic process	IMP IMP: Inferred from mutant phenotype	22360721	MGI
involved in regulation of pH	IMP IMP: Inferred from mutant phenotype	22360721	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	21190881	MGI
part of pyruvate dehydrogenase complex	IDA IDA: Inferred from direct assay	21190881	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pyruvate dehydrogenase kinase, isoenzyme 2

PDH kinase 2	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	pyruvate dehydrogenase 2
pyruvate dehydrogenase kinase, isozyme 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121744	PS10	Inhibitor	98.51%	Unkown
HY-12492	VER-246608	Inhibitor	99.10%	Unkown
HY-19564	JX06		99.78%	Unkown
HY-18676B	ILK-IN-2		99.41%	Unkown
HY-RS10276	PDK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16924	Pdk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23367	Pdk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pdk2	NCBI	NCBI:5164

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