Pbx1 - pre B cell leukemia homeobox 1 Gene

Mus musculus

Also known as Pbx-1; 2310056B04Rik; D230003C07Rik

Gene ID: 18514 | Gene type: protein coding

About Pbx1

Summary

This gene encodes a homeobox protein that belongs to the three-amino-acid loop extension/Pre-B cell leukemia transcription factor (TALE/PBX) family of proteins. The encoded protein is involved in several biological processes during embryogenesis including steroidogenesis, sexual development and the maintenance of hematopoietic stem cells. This protein functions in the development of several organ systems and plays a role in skeletal patterning and programming. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Pbx1 Products(4)

mRNA	Protein	Name
NM_001291508.1	NP_001278437.1	pre-B-cell leukemia transcription factor 1 isoform b
NM_001291509.1	NP_001278438.1	pre-B-cell leukemia transcription factor 1 isoform d
NM_008783.3	NP_032809.1	pre-B-cell leukemia transcription factor 1 isoform b
NM_183355.3	NP_899198.1	pre-B-cell leukemia transcription factor 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9315626	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19799567	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	32190943	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	33795231	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	14764653	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	32190943	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9315626	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15634706	MGI
enables sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	17049510	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	22560297	MGI
acts upstream of or within adrenal gland development	IMP IMP: Inferred from mutant phenotype	14595835	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	11912494	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	11566859	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IDA IDA: Inferred from direct assay	12591246	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15944191	MGI
acts upstream of or within embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	11468159	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	16672333	MGI
acts upstream of or within embryonic organ development	IMP IMP: Inferred from mutant phenotype	15581866	MGI
acts upstream of or within embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	11566859	MGI
involved in natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	32190943	MGI
acts upstream of or within negative regulation of neuron differentiation	IGI IGI: Inferred from genetic interaction	18164701	MGI
acts upstream of or within positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	22560297	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	15944191	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15944191	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19799567	MGI
acts upstream of or within proximal/distal pattern formation	IGI IGI: Inferred from genetic interaction	16672333	MGI
acts upstream of or within proximal/distal pattern formation	IMP IMP: Inferred from mutant phenotype	11566859	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11566859	MGI
acts upstream of or within regulation of ossification	IMP IMP: Inferred from mutant phenotype	11566859	MGI
acts upstream of or within spleen development	IGI IGI: Inferred from genetic interaction	15944191	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	15944191	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	15944191	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	15581866	MGI
acts upstream of or within urogenital system development	IMP IMP: Inferred from mutant phenotype	14595835	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12724421	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9315626	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	9405651	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pre-B-cell leukemia transcription factor 1

homeobox protein PBX1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153916	TCRS-417		99.13%	Unkown
HY-RS10106	PBX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20320	Pbx1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26828	Pbx1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pbx1	NCBI	NCBI:5087

Name
Email *

	Sorry, but the email address you supplied was invalid.