Ntf3 - neurotrophin 3 Gene

Mus musculus

Also known as Nt3; HDNF; NGF-2; Ntf-3

Gene ID: 18205 | Gene type: protein coding

About Ntf3

Summary

This gene encodes a member of the neurotrophins that have a wide variety of functions in both neural and non-neural tissues. The encoded preproprotein undergoes proteolytic processing to generate a noncovalently linked homodimeric mature protein that can bind to the transmembrane Receptor Tyrosine Kinases to initiate a series of signaling events. Mice lacking the encoded protein exhibit severe defects in the peripheral nervous system including a complete lack of spinal proprioceptive afferents and their peripheral sense organs. [provided by RefSeq, Sep 2016]

Ntf3 Products(5)

mRNA	Protein	Name
NM_001164034.2	NP_001157506.1	neurotrophin-3 isoform a
NM_001164035.2	NP_001157507.1	neurotrophin-3 isoform a
NM_001410128.1	NP_001397057.1	neurotrophin-3 isoform b preproprotein
NM_001410129.1	NP_001397058.1	neurotrophin-3 isoform c
NM_008742.4	NP_032768.1	neurotrophin-3 isoform b preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11684666	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	15550985	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	8861722	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	10195193	MGI
acts upstream of or within enteric nervous system development	IMP IMP: Inferred from mutant phenotype	15497153	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	9736028	MGI
acts upstream of or within generation of neurons	IGI IGI: Inferred from genetic interaction	16142215	MGI
acts upstream of or within glial cell fate determination	IMP IMP: Inferred from mutant phenotype	10384880	MGI
acts upstream of or within mechanoreceptor differentiation	IGI IGI: Inferred from genetic interaction	15376326	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	19915564	MGI
acts upstream of or within nerve development	IMP IMP: Inferred from mutant phenotype	7605630	MGI
acts upstream of or within neuromuscular synaptic transmission	IDA IDA: Inferred from direct assay	11978828	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	19915564	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	8809809	MGI
acts upstream of or within peripheral nervous system development	IMP IMP: Inferred from mutant phenotype	8630254	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12741988	MGI
acts upstream of or within regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	16516892	MGI
acts upstream of or within smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	15497153	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	14715936	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neurotrophin-3

nerve growth factor 2

neurotrophic factor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09616	NTF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20313	Ntf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26821	Ntf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ntf3	NCBI	NCBI:4908

Name
Email *

	Sorry, but the email address you supplied was invalid.