Nrxn3 - neurexin III Gene

Mus musculus

Gene ID: 18191 | Gene type: protein coding

About Nrxn3

Summary

This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. [provided by RefSeq, Dec 2012]

Nrxn3 Products(3)

mRNA	Protein	Name
NM_001198587.3	NP_001185516.2	neurexin 3 isoform 1 precursor
NM_001252074.2	NP_001239003.1	neurexin 3 isoform 3 precursor
NM_172544.3	NP_766132.2	neurexin 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel regulator activity	IGI IGI: Inferred from genetic interaction	12827191	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19816407	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	12827191	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	27133466	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	27133466	MGI
acts upstream of or within neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	12827191	MGI
involved in postsynaptic density assembly	IDA IDA: Inferred from direct assay	27133466	MGI
involved in postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	27133466	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	26030848	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	26030848	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	26030848	MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP IMP: Inferred from mutant phenotype	26030848	MGI
acts upstream of or within synapse assembly	IGI IGI: Inferred from genetic interaction	12827191	MGI
involved in trans-synaptic signaling	IDA IDA: Inferred from direct assay	26030848	MGI
involved in trans-synaptic signaling	IMP IMP: Inferred from mutant phenotype	26030848	MGI
involved in trans-synaptic signaling, modulating synaptic transmission	IDA IDA: Inferred from direct assay	36205393	MGI
involved in trans-synaptic signaling, modulating synaptic transmission	IEP IEP: Inferred from expression pattern	36205393	MGI
involved in trans-synaptic signaling, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	36205393	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	26030848	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	26030848	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26030848	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	36205393	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	26030848	MGI
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	35550065	MGI
is active in presynaptic active zone membrane	IMP IMP: Inferred from mutant phenotype	35550065	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	34135511	MGI
part of protein-containing complex	IPI IPI: Inferred from physical interaction	24613359	MGI
part of trans-synaptic protein complex	IDA IDA: Inferred from direct assay	34135511	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neurexin 3

neurexin-3-alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09585	NRXN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20071	Nrxn3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26575	Nrxn3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nrxn3	NCBI	NCBI:9369

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