2. Gene
  3. Nppb - natriuretic peptide type B Gene

Nppb - natriuretic peptide type B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as BNF; BNP; Iso-ANP

Gene ID: 18158 | Gene type: protein coding

About Nppb

Summary

This gene encodes a secreted protein that belongs to the family of natriuretic peptides. Its precursor protein is processed to generate the active mature peptide. The mature peptide is a cardiac hormone that plays a role in ventricular remodeling as well as blood pressure regulation. Mice lacking this gene exhibit cardiac fibrosis. In humans this gene is associated with congestive heart failure, low bone-mineral density and postmenopausal osteoporosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]

Nppb Products(2)

mRNA Protein Name
NM_001287348.2 NP_001274277.1 natriuretic peptides B isoform 2 preproprotein
NM_008726.6 NP_032752.1 natriuretic peptides B isoform 1 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
33245046 MGI
Biological Process GO Annotation Evidence Reference Source
involved in MAPK cascade IDA
IDA: Inferred from direct assay
33245046 MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress IDA
IDA: Inferred from direct assay
24137001 MGI
involved in coronary vasculature development IDA
IDA: Inferred from direct assay
33245046 MGI
involved in endothelial cell proliferation IDA
IDA: Inferred from direct assay
33245046 MGI
involved in homeostasis of number of cells IDA
IDA: Inferred from direct assay
33245046 MGI
involved in response to nutrient levels IDA
IDA: Inferred from direct assay
33245046 MGI
involved in response to oxygen levels IDA
IDA: Inferred from direct assay
33245046 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

natriuretic peptides B

brain natriuretic factor prohormone

brain natriuretic peptide

gamma-brain natriuretic peptide

natriuretic peptide precursor type B

preproBNP

proBNP

type-B natriuretic factor

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101012 NPPB Inhibitor 99.78% Unkown
HY-153392 TYA-018 Inhibitor 99.84% Unkown
HY-RS09495 NPPB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16787 Nppb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23227 Nppb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nppb NCBI NCBI:4879