Notch3 - notch 3 Gene

Mus musculus

Also known as N3; hpbk

Gene ID: 18131 | Gene type: protein coding

About Notch3

Summary

Enables enzyme binding activity. Involved in Notch signaling pathway and positive regulation of smooth muscle cell proliferation. Acts upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus and plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study CADASIL 1 and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Orthologous to human NOTCH3 (Notch receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Notch3 Products(1)

mRNA	Protein	Name
NM_008716.3	NP_032742.1	neurogenic locus notch homolog protein 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	17573339	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9111338	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Notch signaling pathway	IDA IDA: Inferred from direct assay	19855400	MGI
acts upstream of or within artery morphogenesis	IMP IMP: Inferred from mutant phenotype	23117660	MGI
acts upstream of or within forebrain development	IGI IGI: Inferred from genetic interaction	16120638	MGI
involved in glomerular capillary formation	IEP IEP: Inferred from expression pattern	15821257	MGI
acts upstream of or within negative regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	15064243	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15064243	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23117660	MGI
acts upstream of neuroblast differentiation	IMP IMP: Inferred from mutant phenotype	15064243	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15064243	MGI
acts upstream of or within neuron fate commitment	IGI IGI: Inferred from genetic interaction	16120638	MGI
involved in positive regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	19855400	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23117660	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	21191019	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17079689	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neurogenic locus notch homolog protein 3

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15670	BMS-906024	Inhibitor	99.91%	Phase 1
HY-12860	BMS-986115	Inhibitor	99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15827	NSC 405020	Inhibitor	99.63%	Unkown
HY-136522	S2116		98.15%	Unkown
HY-RS09451	NOTCH3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-136523	S2157		98.44%	Unkown
HY-RS17213	Notch3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23665	Notch3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Notch3	NCBI	NCBI:4854

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