Mycn - v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived Gene

Mus musculus

Also known as Nmyc; N-myc; Nmyc1; Nmyc-1; c-nmyc; bHLHe37

Gene ID: 18109 | Gene type: protein coding

About Mycn

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and kinase binding activity. Involved in negative regulation of Reactive Oxygen Species metabolic process and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic digit morphogenesis; negative regulation of astrocyte differentiation; and skeletal system morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Human ortholog(s) of this gene implicated in Feingold syndrome. Orthologous to human MYCN (MYCN proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Mycn Products(1)

mRNA	Protein	Name
NM_008709.3	NP_032735.3	N-myc proto-oncogene protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10229200	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of astrocyte differentiation	IDA IDA: Inferred from direct assay	18640244	MGI
acts upstream of positive effect autosome genomic imprinting	IMP IMP: Inferred from mutant phenotype	21047779	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	15716345	MGI
acts upstream of or within cartilage condensation	IMP IMP: Inferred from mutant phenotype	17360777	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15716345	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	17360777	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	17360777	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15716345	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	15716345	MGI
acts upstream of or within negative regulation of astrocyte differentiation	IDA IDA: Inferred from direct assay	18640244	MGI
involved in negative regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	17357786	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17357786	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15716345	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	17360777	MGI
acts upstream of or within positive regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	17360777	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21047779	MGI
acts upstream of or within regulation of inner ear auditory receptor cell differentiation	IGI IGI: Inferred from genetic interaction	23022312	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	15716345	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

N-myc proto-oncogene protein

neuroblastoma myc-related oncogene 1

v-myc myelocytomatosis viral related oncogene, neuroblastoma derived

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-11103	Sitaxsentan sodium	Antagonist	98.83%	Unkown

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145765	JQAD1		98.24%	Unkown
HY-156443	YG1702	Inhibitor	99.94%	Unkown
HY-112273	CD532	Inhibitor	98.86%	Unkown
HY-112273A	CD532 hydrochloride	Inhibitor	99.62%	Unkown
HY-171768	SK2187	Degrader	/	Unkown
HY-171767	SK2188		/	Unkown
HY-168439	HLB-0532259	Degrader	98.30%	Unkown
HY-171769	dAurAB2	Degrader	/	Unkown
HY-152032	LSD1-IN-23	Inhibitor	/	Unkown
HY-158062	LC-1-40		/	Unkown
HY-RS08884	MYCN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17293	Mycn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23748	Mycn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mycn	NCBI	NCBI:4613

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