2. Gene
  3. Nek1 - NIMA (never in mitosis gene a)-related expressed kinase 1 Gene

Nek1 - NIMA (never in mitosis gene a)-related expressed kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as kat; D8Ertd790e

Gene ID: 18004 | Gene type: protein coding

About Nek1

Summary

Enables 14-3-3 protein binding activity. Involved in regulation of DNA damage checkpoint. Acts upstream of or within several processes, including cellular response to DNA damage stimulus; response to ionizing radiation; and spermatogenesis. Located in centrosome and nucleus. Is expressed in several structures, including central nervous system; ganglia; gonad; lung; and spleen. Used to study autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asphyxiating thoracic dystrophy; and short-rib thoracic dysplasia 6 with or without polydactyly. Orthologous to human NEK1 (NIMA related kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nek1 Products(9)

mRNA Protein Name
NM_001293637.1 NP_001280566.1 serine/threonine-protein kinase Nek1 isoform 1
NM_001293638.1 NP_001280567.1 serine/threonine-protein kinase Nek1 isoform 2
NM_001293639.1 NP_001280568.1 serine/threonine-protein kinase Nek1 isoform 4
NM_001414226.1 NP_001401155.1 serine/threonine-protein kinase Nek1 isoform 5
NM_001414227.1 NP_001401156.1 serine/threonine-protein kinase Nek1 isoform 6
NM_001414228.1 NP_001401157.1 serine/threonine-protein kinase Nek1 isoform 7
NM_001414229.1 NP_001401158.1 serine/threonine-protein kinase Nek1 isoform 8
NM_001414230.1 NP_001401159.1 serine/threonine-protein kinase Nek1 isoform 9
NM_175089.4 NP_780298.2 serine/threonine-protein kinase Nek1 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 14-3-3 protein binding IDA
IDA: Inferred from direct assay
28235073 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
15604234 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
10618398 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
10618398 MGI
involved in regulation of DNA damage checkpoint IMP
IMP: Inferred from mutant phenotype
18843199 MGI
acts upstream of or within response to ionizing radiation IMP
IMP: Inferred from mutant phenotype
15604234 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
10618398 MGI
Cellular Component GO Annotation Evidence Reference Source
located in centrosome IDA
IDA: Inferred from direct assay
16267153 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19699716 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase Nek1

NIMA-related kinase 1

NY-REN-55 antigen

Nek1 serine/threonine- and tyrosine-specific protein kinase

kidney, anemia and testis

never in mitosis A-related kinase 1

nimA-related protein kinase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-144425 BSc5367 98.65% Unkown
HY-103646 CK7 Inhibitor 99.72% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nek1 NCBI NCBI:4750