Ncf1 - neutrophil cytosolic factor 1 Gene

Mus musculus

Also known as NOXO2; Ncf-1; NCF-47K; p47phox; p47-phox; p47

Gene ID: 17969 | Gene type: protein coding

About Ncf1

Summary

Enables superoxide-generating NADPH Oxidase activator activity. Acts upstream of or within several processes, including cellular defense response; hydrogen peroxide biosynthetic process; and neutrophil-mediated killing of symbiont cell. Located in cytoplasm and membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system; integumental system; and sensory organ. Used to study chronic granulomatous disease. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome; autosomal recessive chronic granulomatous disease cytochrome b-positive type I; and chronic granulomatous disease. Orthologous to several human genes including NCF1 (neutrophil cytosolic factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncf1 Products(2)

mRNA	Protein	Name
NM_001286037.1	NP_001272966.1	neutrophil cytosol factor 1 isoform a
NM_010876.4	NP_035006.3	neutrophil cytosol factor 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9490028	MGI
enables superoxide-generating NADPH oxidase activator activity	IDA IDA: Inferred from direct assay	8119734	MGI
enables superoxide-generating NADPH oxidase activator activity	IMP IMP: Inferred from mutant phenotype	10987289	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular defense response	IMP IMP: Inferred from mutant phenotype	7650482	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	11907569	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	9116268	MGI
acts upstream of or within defense response to fungus	IMP IMP: Inferred from mutant phenotype	10714686	MGI
acts upstream of or within epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	10987289	MGI
acts upstream of or within hydrogen peroxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	15258578	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	11867678	MGI
acts upstream of or within leukocyte mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	17526748	MGI
acts upstream of or within leukotriene metabolic process	IMP IMP: Inferred from mutant phenotype	11867678	MGI
acts upstream of or within neutrophil-mediated killing of fungus	IMP IMP: Inferred from mutant phenotype	11907569	MGI
acts upstream of or within neutrophil-mediated killing of gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	11907569	MGI
acts upstream of or within respiratory burst	IMP IMP: Inferred from mutant phenotype	15626477	MGI
acts upstream of or within respiratory burst involved in defense response	IMP IMP: Inferred from mutant phenotype	10714686	MGI
acts upstream of or within response to bacterium	IMP IMP: Inferred from mutant phenotype	10678931	MGI
acts upstream of or within response to yeast	IMP IMP: Inferred from mutant phenotype	10714686	MGI
acts upstream of or within superoxide anion generation	IMP IMP: Inferred from mutant phenotype	10725280	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11156938	MGI
located in membrane	IDA IDA: Inferred from direct assay	26021615	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neutrophil cytosol factor 1

47 kDa neutrophil oxidase factor	NADPH oxidase subunit (47 kD)
NADPH oxidase subunit (47kDa)	neutrophil NADPH oxidase factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09077	NCF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20305	Ncf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26813	Ncf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ncf1	NCBI	NCBI:653361

Name
Email *

	Sorry, but the email address you supplied was invalid.